Metabolic flexibility during late pregnancy is associated with neonatal adiposity

Rachel A. Tinius; Maire M. Blankenship; Karen E. Furgal; W. Todd Cade; Cathryn Duchette; Kevin J. Pearson; Jill M. Maples

doi:10.1139/apnm-2020-1005

Metabolic flexibility during late pregnancy is associated with neonatal adiposity

Rachel A. Tinius, Maire M. Blankenship, Karen E. Furgal, W. Todd Cade, Cathryn Duchette, Kevin J. Pearson, Jill M. Maples

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The aim of this study was to determine the relationships between maternal metabolic flexibility during pregnancy and neonatal health outcomes. Percent change in lipid oxidation (before and after a high-fat meal) was calculated as the measure of “metabolic flexibility”. Neonatal adiposity was assessed within 48 h of delivery by skinfold anthropometry. Metabolic flexibility (r = _0.271, p = 0.034), maternal HOMA-IR (r = 0.280, p = 0.030), and maternal body mass index (r = 0.299, p = 0.018) were correlated with neonatal subscapular skinfold (i.e., measure of neonatal adiposity). Clinical Trail Registration Number: NCT03504319.

Original language	English
Pages (from-to)	404-407
Number of pages	4
Journal	Applied Physiology, Nutrition and Metabolism
Volume	46
Issue number	4
DOIs	https://doi.org/10.1139/apnm-2020-1005
State	Published - 2021

Bibliographical note

Publisher Copyright:
© 2021, Canadian Science Publishing. All rights reserved.

Keywords

Lipid oxidation
Neonates
Pregnant
Substrate shifting

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Physiology
Nutrition and Dietetics
Physiology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1139/apnm-2020-1005

Cite this

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title = "Metabolic flexibility during late pregnancy is associated with neonatal adiposity",

abstract = "The aim of this study was to determine the relationships between maternal metabolic flexibility during pregnancy and neonatal health outcomes. Percent change in lipid oxidation (before and after a high-fat meal) was calculated as the measure of “metabolic flexibility”. Neonatal adiposity was assessed within 48 h of delivery by skinfold anthropometry. Metabolic flexibility (r = _0.271, p = 0.034), maternal HOMA-IR (r = 0.280, p = 0.030), and maternal body mass index (r = 0.299, p = 0.018) were correlated with neonatal subscapular skinfold (i.e., measure of neonatal adiposity). Clinical Trail Registration Number: NCT03504319.",

keywords = "Lipid oxidation, Neonates, Pregnant, Substrate shifting",

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doi = "10.1139/apnm-2020-1005",

language = "English",

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T1 - Metabolic flexibility during late pregnancy is associated with neonatal adiposity

AU - Tinius, Rachel A.

AU - Blankenship, Maire M.

AU - Furgal, Karen E.

AU - Cade, W. Todd

AU - Duchette, Cathryn

AU - Pearson, Kevin J.

AU - Maples, Jill M.

PY - 2021

Y1 - 2021

N2 - The aim of this study was to determine the relationships between maternal metabolic flexibility during pregnancy and neonatal health outcomes. Percent change in lipid oxidation (before and after a high-fat meal) was calculated as the measure of “metabolic flexibility”. Neonatal adiposity was assessed within 48 h of delivery by skinfold anthropometry. Metabolic flexibility (r = _0.271, p = 0.034), maternal HOMA-IR (r = 0.280, p = 0.030), and maternal body mass index (r = 0.299, p = 0.018) were correlated with neonatal subscapular skinfold (i.e., measure of neonatal adiposity). Clinical Trail Registration Number: NCT03504319.

AB - The aim of this study was to determine the relationships between maternal metabolic flexibility during pregnancy and neonatal health outcomes. Percent change in lipid oxidation (before and after a high-fat meal) was calculated as the measure of “metabolic flexibility”. Neonatal adiposity was assessed within 48 h of delivery by skinfold anthropometry. Metabolic flexibility (r = _0.271, p = 0.034), maternal HOMA-IR (r = 0.280, p = 0.030), and maternal body mass index (r = 0.299, p = 0.018) were correlated with neonatal subscapular skinfold (i.e., measure of neonatal adiposity). Clinical Trail Registration Number: NCT03504319.

KW - Lipid oxidation

KW - Neonates

KW - Pregnant

KW - Substrate shifting

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JO - Applied Physiology, Nutrition and Metabolism

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Metabolic flexibility during late pregnancy is associated with neonatal adiposity

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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