Metabolic flexibility during late pregnancy is associated with neonatal adiposity

Rachel A. Tinius, Maire M. Blankenship, Karen E. Furgal, W. Todd Cade, Cathryn Duchette, Kevin J. Pearson, Jill M. Maples

Research output: Contribution to journalArticlepeer-review


The aim of this study was to determine the relationships between maternal metabolic flexibility during pregnancy and neonatal health outcomes. Percent change in lipid oxidation (before and after a high-fat meal) was calculated as the measure of “metabolic flexibility”. Neonatal adiposity was assessed within 48 h of delivery by skinfold anthropometry. Metabolic flexibility (r = _0.271, p = 0.034), maternal HOMA-IR (r = 0.280, p = 0.030), and maternal body mass index (r = 0.299, p = 0.018) were correlated with neonatal subscapular skinfold (i.e., measure of neonatal adiposity). Clinical Trail Registration Number: NCT03504319.

Original languageEnglish
Pages (from-to)404-407
Number of pages4
JournalApplied Physiology, Nutrition and Metabolism
Issue number4
StatePublished - 2021

Bibliographical note

Funding Information:
Thank you to Alyssa Olenick and Bailey Pitts for data collection assistance. Funding was provided by the National Institutes of Health (NIH) National Institute of General Medical Sciences (NIGMS) Institutional Development Award (IDeA), Grant 5P20GM103436, and by the Western Kentucky University Research and Creative Activities Program (RCAP), no. 17-8011. Author contributions: Study design: R.A.T., M.M.B., W.T.C., K.J.P., and J.M.M. Data collection procedures: R.A.T., M.M.B., J.M.M., K.E.F., and C.D. Wrote manuscript: R.A.T. and J.M.M. Approved final manuscript version: R.A.T., M.M.B., K.E.F.,W.T.C., K.J.P., C.D., and J.M.M.

Publisher Copyright:
© 2021, Canadian Science Publishing. All rights reserved.


  • Lipid oxidation
  • Neonates
  • Pregnant
  • Substrate shifting

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Nutrition and Dietetics
  • Physiology (medical)


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