Metabolic Products of Microorganisms. 2341)Urdamycins, New Angucycline Antibiotics from Streptomyces Fradiae I. Isolation, Characterization and Biological Properties

Hannelore Drautz, Jurgen Rohr, Hans ZäHner, Axel Zeeck

Research output: Contribution to journalArticlepeer-review

126 Scopus citations

Abstract

The colored urdamycins A to F, six new angucycline antibiotics produced by Streptomyces fradiae strain Tu 2717, were detected by chemical screening. They are biologically active against Gram-positive bacteria and stem cells of murine LI210 leukemia. The urda-myces are glycosides and differ in their aglycones, which can be liberated by acidic hydrolysis besides the sugars D-olivose and L-rhodinose. The structure of the main compound, urda-mycin A (3b), follows from the spectroscopic and chemical data in connection with an X-ray analysis. The aglycone urdamycinone A (3a) is identical with aquayamycin. The structures of urdamycin B (4b), E (3c), F and partial structures of urdamycin C and D, will be presented in a subsequent paper. The new term “angucycline/angucyclinone” is used for an increasing group of related antibiotics.

Original languageEnglish
Pages (from-to)1657-1669
Number of pages13
JournalJournal of Antibiotics
Volume39
Issue number12
DOIs
StatePublished - 1986

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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