Metabolic reprogram associated with epithelial-mesenchymal transition in tumor progression and metastasis

Yifan Wang, Chenfang Dong, Binhua P. Zhou

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations

Abstract

Epithelial-mesenchymal Transition (EMT) is a de-differentiation program that imparts tumor cells with the phenotypic and cellular plasticity required for drug resistance, metastasis, and recurrence. This dynamic and reversible events is governed by a network of EMT-transcription factors (EMT-TFs) through epigenetic regulation. Many chromatin modifying-enzymes utilize metabolic intermediates as cofactors or substrates; this suggests that EMT is subjected to the metabolic regulation. Conversely, EMT rewires metabolic program to accommodate cellular changes during EMT. Here we summarize the latest findings regarding the epigenetic regulation of EMT, and discuss the mutual interactions among metabolism, epigenetic regulation, and EMT. Finally, we provide perspectives of how this interplay contributes to cellular plasticity, which may result in the clinical manifestation of tumor heterogeneity.

Original languageEnglish
Pages (from-to)172-184
Number of pages13
JournalGenes and Diseases
Volume7
Issue number2
DOIs
StatePublished - Jun 2020

Bibliographical note

Publisher Copyright:
© 2019 Chongqing Medical University

Keywords

  • Epigenetics
  • Epithelial-mesenchymal transition
  • Heterogeneity
  • Metabolism
  • Plasticity

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics(clinical)
  • Cell Biology

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