Metabolic reprogramming of the tumour microenvironment

Yazhi Xing, Shimin Zhao, Binhua P. Zhou, Jun Mi

Research output: Contribution to journalReview articlepeer-review

77 Scopus citations

Abstract

Tumour cells, stromal cells and the stroma comprise the tumour microenvironment. The metabolism of both tumour cells and several types of tumour stromal cells, such as cancer-associated fibroblasts and tumour-associated macrophages, is reprogrammed. Current studies have found that stromal cells promote tumour progression and metastasis, through not only the paracrine secretion of cytokines or chemokines, but also intermediate metabolites. Here, we summarize the latest insights into the mechanism of metabolic reprogramming in cancer cells, cancer-associated fibroblasts and tumour-associated macrophages, and their potential roles in tumour progression and metastasis.

Original languageEnglish
Pages (from-to)3892-3898
Number of pages7
JournalFEBS Journal
Volume282
Issue number20
DOIs
StatePublished - Oct 1 2015

Bibliographical note

Publisher Copyright:
© 2015 FEBS.

Keywords

  • Aerobic glycolysis
  • Warburg effect
  • cancer-associated fibroblast
  • epigenetic regulation
  • metabolic reprogramming
  • metabolites shuttling
  • oxidative phosphorylation
  • tumor progression
  • tumour microenvironment
  • tumour-associated macrophage

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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