Cancer-associated fibroblasts (CAFs) are major participants in the crosstalk between tumor cells and their microenvironment. CAFs provide not only multiple soluble factors but also metabolic fuels to promote tumor growth, invasion, and metastasis. We discuss recent developments delineating the effects of metabolic symbiosis between CAFs and tumor cells on tumor growth.
|Journal||Molecular and Cellular Oncology|
|State||Published - Jan 2 2016|
Bibliographical noteFunding Information:
We apologize to the many contributors to this field whose work is important but could not be cited due to space limitations. Our study is supported by the grants from NIH (RO1s CA125454 and CA188118), DOD Break-through Award (BC140733P1), the Mary Kay Ash Foundation (to B. P. Zhou), and the National Natural Science Foundation of China (81402432 to J. Liu).
© 2016, © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2016, © Jingyi Liu, Jun Mi and Binhua P. Zhou.
- metabolic symbiosis
- tumor microenvironment
ASJC Scopus subject areas
- Molecular Medicine
- Cancer Research