Metabolic rewiring in cancer-associated fibroblasts provides a niche for oncogenesis and metastatic dissemination

Jingyi Liu; Jun Mi; Binhua P. Zhou

doi:10.1080/23723556.2015.1056331

Metabolic rewiring in cancer-associated fibroblasts provides a niche for oncogenesis and metastatic dissemination

Jingyi Liu, Jun Mi, Binhua P. Zhou

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Cancer-associated fibroblasts (CAFs) are major participants in the crosstalk between tumor cells and their microenvironment. CAFs provide not only multiple soluble factors but also metabolic fuels to promote tumor growth, invasion, and metastasis. We discuss recent developments delineating the effects of metabolic symbiosis between CAFs and tumor cells on tumor growth.

Original language	English
Article number	e1056331
Journal	Molecular and Cellular Oncology
Volume	3
Issue number	1
DOIs	https://doi.org/10.1080/23723556.2015.1056331
State	Published - Jan 2 2016

Bibliographical note

Funding Information:
We apologize to the many contributors to this field whose work is important but could not be cited due to space limitations. Our study is supported by the grants from NIH (RO1s CA125454 and CA188118), DOD Break-through Award (BC140733P1), the Mary Kay Ash Foundation (to B. P. Zhou), and the National Natural Science Foundation of China (81402432 to J. Liu).

Publisher Copyright:
© 2016, © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2016, © Jingyi Liu, Jun Mi and Binhua P. Zhou.

Keywords

Alpha-ketoglutarate
IDH
cancer-associated
fibroblast
metabolic symbiosis
metastasis
tumor microenvironment

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/23723556.2015.1056331

Cite this

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abstract = "Cancer-associated fibroblasts (CAFs) are major participants in the crosstalk between tumor cells and their microenvironment. CAFs provide not only multiple soluble factors but also metabolic fuels to promote tumor growth, invasion, and metastasis. We discuss recent developments delineating the effects of metabolic symbiosis between CAFs and tumor cells on tumor growth.",

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AU - Mi, Jun

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Metabolic rewiring in cancer-associated fibroblasts provides a niche for oncogenesis and metastatic dissemination

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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