Abstract
Cancer-associated fibroblasts (CAFs) are major participants in the crosstalk between tumor cells and their microenvironment. CAFs provide not only multiple soluble factors but also metabolic fuels to promote tumor growth, invasion, and metastasis. We discuss recent developments delineating the effects of metabolic symbiosis between CAFs and tumor cells on tumor growth.
Original language | English |
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Article number | e1056331 |
Journal | Molecular and Cellular Oncology |
Volume | 3 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2 2016 |
Bibliographical note
Publisher Copyright:© 2016, © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2016, © Jingyi Liu, Jun Mi and Binhua P. Zhou.
Keywords
- Alpha-ketoglutarate
- IDH
- cancer-associated
- fibroblast
- metabolic symbiosis
- metastasis
- tumor microenvironment
ASJC Scopus subject areas
- Molecular Medicine
- Cancer Research