TY - JOUR
T1 - Metabolomic profiling of anaerobic and aerobic energy metabolic pathways in chronic obstructive pulmonary disease
AU - Xue, Mingshan
AU - Zeng, Yifeng
AU - Lin, Runpei
AU - Qu, Hui Qi
AU - Zhang, Teng
AU - Zhang, Xiaohua Douglas
AU - Liang, Yueting
AU - Zhen, Yingjie
AU - Chen, Hao
AU - Huang, Zhifeng
AU - Hu, Haisheng
AU - Zheng, Peiyan
AU - Hakonarson, Hakon
AU - Zhou, Luqian
AU - Sun, Baoqing
N1 - Publisher Copyright:
© 2021 by the Society for Experimental Biology and Medicine.
PY - 2021/7
Y1 - 2021/7
N2 - While there is no cure for chronic obstructive pulmonary disease (COPD), its progressive nature and the formidable challenge to manage its symptoms warrant a more extensive study of the pathogenesis and related mechanisms. A new emphasis on COPD study is the change of energy metabolism. For the first time, this study investigated the anaerobic and aerobic energy metabolic pathways in COPD using the metabolomic approach. Metabolomic analysis was used to investigate energy metabolites in 140 COPD patients. The significance of energy metabolism in COPD was comprehensively explored by the Global Initiative for Chronic Obstructive Lung Disease–GOLD grading, acute exacerbation vs. stable phase (either clinical stability or four-week stable phase), age group, smoking index, lung function, and COPD Assessment Test (CAT) score. Through comprehensive evaluation, we found that COPD patients have a significant imbalance in the aerobic and anaerobic energy metabolisms in resting state, and a high tendency of anaerobic energy supply mechanism that correlates positively with disease progression. This study highlighted the significance of anaerobic and low-efficiency energy supply pathways in lung injury and linked it to the energy-inflammation-lung ventilatory function and the motion limitation mechanism in COPD patients, which implies a novel therapeutic direction for this devastating disease.
AB - While there is no cure for chronic obstructive pulmonary disease (COPD), its progressive nature and the formidable challenge to manage its symptoms warrant a more extensive study of the pathogenesis and related mechanisms. A new emphasis on COPD study is the change of energy metabolism. For the first time, this study investigated the anaerobic and aerobic energy metabolic pathways in COPD using the metabolomic approach. Metabolomic analysis was used to investigate energy metabolites in 140 COPD patients. The significance of energy metabolism in COPD was comprehensively explored by the Global Initiative for Chronic Obstructive Lung Disease–GOLD grading, acute exacerbation vs. stable phase (either clinical stability or four-week stable phase), age group, smoking index, lung function, and COPD Assessment Test (CAT) score. Through comprehensive evaluation, we found that COPD patients have a significant imbalance in the aerobic and anaerobic energy metabolisms in resting state, and a high tendency of anaerobic energy supply mechanism that correlates positively with disease progression. This study highlighted the significance of anaerobic and low-efficiency energy supply pathways in lung injury and linked it to the energy-inflammation-lung ventilatory function and the motion limitation mechanism in COPD patients, which implies a novel therapeutic direction for this devastating disease.
KW - Chronic obstructive pulmonary disease
KW - anaerobic glycolysis
KW - energy metabolism cycle
KW - metabolomics
KW - tricarboxylic acid cycle
UR - http://www.scopus.com/inward/record.url?scp=85105741144&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85105741144&partnerID=8YFLogxK
U2 - 10.1177/15353702211008808
DO - 10.1177/15353702211008808
M3 - Article
C2 - 33957804
AN - SCOPUS:85105741144
SN - 1535-3702
VL - 246
SP - 1586
EP - 1596
JO - Experimental Biology and Medicine
JF - Experimental Biology and Medicine
IS - 14
ER -