TY - JOUR
T1 - Metal-induced oxidative stress and signal transduction
AU - Leonard, Stephen S.
AU - Harris, Gabriel K.
AU - Shi, Xianglin
PY - 2004/12/15
Y1 - 2004/12/15
N2 - Occupational and environmental exposures to metals are associated with the development of various cancers. Although carcinogenesis caused by metals has been intensively investigated, the mechanisms of action, especially at the molecular level, are still unclear. Accumulating evidence indicates that reactive oxygen species generated by metals may play an important role in the etiology of disease. This review covers recent advances in (1) metal-induced generation of reactive oxygen species; (2) the receptors, kinases, and nuclear transcription factors affected by metals and metal-induced oxidative stress, including growth factor receptors, src kinase, ras signaling, mitogen-activated protein kinases, the phosphoinositide 3-phosphate/Akt pathway, nuclear transcription factor κB, activator protein 1, p53, nuclear factor of activated T cells, and hypoxia-inducible factor 1; and (3) global cellular phenomena (signal transduction, cell cycle regulation, and apoptosis) associated with metal-induced ROS production and gene expression.
AB - Occupational and environmental exposures to metals are associated with the development of various cancers. Although carcinogenesis caused by metals has been intensively investigated, the mechanisms of action, especially at the molecular level, are still unclear. Accumulating evidence indicates that reactive oxygen species generated by metals may play an important role in the etiology of disease. This review covers recent advances in (1) metal-induced generation of reactive oxygen species; (2) the receptors, kinases, and nuclear transcription factors affected by metals and metal-induced oxidative stress, including growth factor receptors, src kinase, ras signaling, mitogen-activated protein kinases, the phosphoinositide 3-phosphate/Akt pathway, nuclear transcription factor κB, activator protein 1, p53, nuclear factor of activated T cells, and hypoxia-inducible factor 1; and (3) global cellular phenomena (signal transduction, cell cycle regulation, and apoptosis) associated with metal-induced ROS production and gene expression.
KW - Carcinogenesis
KW - Free radicals
KW - Metals
KW - Reactive oxygen species
KW - Signal transduction
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U2 - 10.1016/j.freeradbiomed.2004.09.010
DO - 10.1016/j.freeradbiomed.2004.09.010
M3 - Review article
C2 - 15544913
AN - SCOPUS:8544224992
SN - 0891-5849
VL - 37
SP - 1921
EP - 1942
JO - Free Radical Biology and Medicine
JF - Free Radical Biology and Medicine
IS - 12
ER -