Metal-induced toxicity, carcinogenesis, mechanisms and cellular responses

Stephen S. Leonard, Jacquelyn J. Bower, Xianglin Shi

Research output: Contribution to journalReview articlepeer-review

115 Scopus citations


A wide variety of metals have been reported to act as mutagenic and carcinogenic agents in both human and animal studies. The underlying mechanisms are being extensively investigated. Recently, a new sub-discipline of molecular carcinogenesis has surfaced and new techniques and instruments are being developed which allow exploration of the complex biological relationships and signaling pathways involved in response to metal exposure at the molecular level. The 2nd Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis was held at NIOSH in Morgantown, West Virginia, Sept. 8-11, 2002. One hundred thirty scientist from sixteen countries presented their novel findings and investigations of metal-induced carcinogenesis. The conference focused on state-of-the-art research and developments in metal toxicity and carcinogenesis. Emphasis was placed on delineating molecular mechanisms involved in free radical effects, cellular uptake, signaling pathways/interaction, dose response, biomarkers, and resistance mechanisms. This article reviews some of the novel information presented at the conference and discusses future avenues of research in this field.

Original languageEnglish
Pages (from-to)3-10
Number of pages8
JournalMolecular and Cellular Biochemistry
Issue number1-2
StatePublished - Jan 2004


  • AP-1 and MAP kinases
  • Carcinogenesis
  • Metals
  • NF-κB
  • Reactive oxygen species
  • Transcription factors

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology


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