Metal‐Induced Dispersion of Lipid Aggregates: A Simple, Selective, and Sensitive Fluorescent Metal Ion Sensor

Deborah R. Shnek, Daniel W. Pack, Frances H. Arnold, Darryl Y. Sasaki

Research output: Contribution to journalArticlepeer-review

146 Scopus citations

Abstract

A new metal ion sensor capable of detecting nanomolar concentrations (< 1 ppb) of Cu2+ is made from mixed vesicles of a novel pyrene‐labeled metal‐chelating ligand and distearoyl phosphatidylcholine. When copper is added, the fluorescence monomer intensity emitted at 377 nm greatly increases, while the intensity of light emitted at 470 nm decreases. This effect is probably due to the dispersal of the fluorescent lipid throughout the matrix upon metal binding and is depicted schematically below. (Figure Presented.)

Original languageEnglish
Pages (from-to)905-907
Number of pages3
JournalAngewandte Chemie International Edition in English
Volume34
Issue number8
DOIs
StatePublished - May 2 1995

Keywords

  • fluorescent sensors
  • lipids
  • metal ion analysis
  • vesicles

ASJC Scopus subject areas

  • Catalysis
  • Chemistry (all)

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