Metastatic breast cancer mimicking hepatocellular carcinoma: Differences in noninvasive guidelines

Anna H. Bartram, John Lee Villano, Dean M. Ferrera

Research output: Contribution to journalArticlepeer-review


Hepatocellular carcinoma (HCC), unlike most solid tumors, can be diagnosed noninvasively. We present a case that highlights an important clinical difference between two established guidelines: National Cancer Comprehensive Network (NCCN) and Barcelona-2000 EASL Conference (European Association for the Study of the Liver). Our patient had a large liver mass extending into the right atrium with elevation of the alpha-fetoprotein to 1,130 ng/mL. The radiographic and laboratory evidence is sufficient usingNCCN guidelines to initiate palliative treatment for HCC. The Barcelona-2000 EASL Conference guideline for noninvasive diagnosis is restricted to cirrhotic patients. Our patient did not have a history of chronic liver disease or active hepatitis, and a biopsy was performed that demonstrated breast cancer.

Original languageEnglish
Pages (from-to)145-148
Number of pages4
JournalJournal of Gastrointestinal Cancer
Issue number2
StatePublished - Jun 2010


  • AFP
  • Breast cancer
  • HCC
  • Hepatocellular carcinoma
  • Noninvasive diagnosis

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology


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