Methamphetamine acutely alters frontostriatal resting state functional connectivity in healthy young adults

Jessica Weafer, Kathryne Van Hedger, Sarah K. Keedy, Nkemdilim Nwaokolo, Harriet de Wit

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Chronic use of methamphetamine impairs frontostriatal structure and function, which may result in increased incentive-motivational responses to drug cues and decreased regulation of drug-seeking behavior. However, less is known regarding how the drug affects these circuits after acute administration. The current study examined the effects of a single dose of methamphetamine on resting state frontostriatal functional connectivity in healthy volunteers. Participants (n = 22, 12 female) completed two sessions in which they received methamphetamine (20 mg) and placebo before a resting state scan during functional magnetic resonance imaging. Participants also provided self-report measures of euphoria and stimulation at regular intervals. We conducted seed-based voxelwise functional connectivity analyses using three bilateral striatal seed regions: nucleus accumbens (NAcc), caudate, and putamen and compared connectivity following methamphetamine versus placebo administration. Additionally, we conducted correlational analyses to assess if drug-induced changes in functional connectivity were related to changes in subjective response. Methamphetamine increased NAcc functional connectivity with medial frontal regions (ie, orbitofrontal cortex, medial frontal gyrus, and superior frontal gyrus) and decreased NAcc functional connectivity with subgenual anterior cingulate cortex (ACC). Methamphetamine also increased functional connectivity between putamen and left inferior frontal gyrus (IFG), and individuals who displayed greater drug-induced increase in connectivity reported less euphoria and stimulation. These findings provide important information regarding the effects of methamphetamine on brain function in nonaddicted individuals. Further studies will reveal whether such effects contribute to the abuse potential of the drug and whether they are related to the frontostriatal impairments observed after chronic methamphetamine use.

Original languageEnglish
Article numbere12775
JournalAddiction Biology
Volume25
Issue number3
DOIs
StatePublished - May 1 2020

Bibliographical note

Funding Information:
This research was supported by National Institute on Drug Abuse grant R01 DA037011 (H.d.W.) and benefitted from S10OD018448 awarded to the University of Chicago MRI Research Center. J.W. was supported by National Institute on Alcohol Abuse and Alcoholism grant K01 AA024519. K.V.H. was supported by NIMH training grant T32MH020065. The funding agencies had no involvement in the research other than financial support.

Publisher Copyright:
© 2019 Society for the Study of Addiction

Keywords

  • fMRI
  • functional connectivity
  • healthy volunteers
  • methamphetamine
  • resting state
  • striatum

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology
  • Psychiatry and Mental health

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