Methamphetamine Impairs Sexual Motivation but Not Sexual Performance in Male Japanese Quail

B. Levi Bolin, Chana K. Akins

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The present study investigated the effects of chronic pre-exposure to methamphetamine on sexual motivation and performance in male Japanese quail. Quail were pre-exposed to methamphetamine (1.0 or 3.0 mg/kg ip) or saline (ip) once daily for 10 days and locomotor activity was measured. After a 10 day washout period, sexual motivation was measured in a straight-arm runway with visual access to a female at one end. Three to 5 hr after sexual motivation tests, males were allowed to copulate with a receptive female quail and copulatory behavior was assessed. Tests were conducted once per day for 10 days. Results showed that males pre-exposed to methamphetamine had decreased locomotor activity compared to saline controls. Males pre-exposed to METH later ran slower toward a female in the runway and spent less time near her. In contrast, methamphetamine pre-exposed males showed similar copulatory behavior as saline pre-exposed males. The findings suggest that chronic pre-exposure to methamphetamine may impair sexual motivation but not sexual performance. The findings are discussed from a comparative perspective and with regard to their clinical relevance.

Original languageEnglish
Pages (from-to)10-20
Number of pages11
JournalExperimental and Clinical Psychopharmacology
Volume17
Issue number1
DOIs
StatePublished - Feb 2009

Keywords

  • locomotor activity
  • male quail
  • methamphetamine
  • sexual motivation
  • sexual performance

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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