Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase

William F. Maragos, Rebekah Jakel, Dathan Chesnut, Chava B. Pocernich, D. Allan Butterfield, Daret St Clair, Wayne A. Cass

Research output: Contribution to journalArticlepeer-review

47 Scopus citations

Abstract

We have investigated methamphetamine (MA) toxicity in transgenic mice that overexpress the human form of mitochondrial manganese superoxide dismutase (MnSOD). Our results reveal a significant reduction in the long-term depletion of striatal dopamine and protein oxidation following repeated administration of MA in transgenic vs. non-transgenic littermates. These findings support the notion that ROS contribute to MA-induced brain damage and suggest that mitochondria may play an important role in this form of neurodegeneration. (C) 2000 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)218-222
Number of pages5
JournalBrain Research
Volume878
Issue number1-2
DOIs
StatePublished - Sep 29 2000

Bibliographical note

Funding Information:
This work was supported by USPHS Grants NS 01941 to WFM, CA 59835 to DKS, DA 10115 to WAC and AG 10836 to DAB. Electron micrographs were obtained using the University of Kentucky’s Image Facility with the assistance of Ms. Mary Gail Engle.

Keywords

  • Dopamine
  • Manganese superoxide dismutase
  • Methamphetamine
  • Oxidative stress
  • Striatum
  • Transgenic mouse

ASJC Scopus subject areas

  • General Neuroscience
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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