Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase

William F. Maragos; Rebekah Jakel; Dathan Chesnut; Chava B. Pocernich; D. Allan Butterfield; Daret St Clair; Wayne A. Cass

doi:10.1016/S0006-8993(00)02707-4

Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase

William F. Maragos, Rebekah Jakel, Dathan Chesnut, Chava B. Pocernich, D. Allan Butterfield, Daret St Clair, Wayne A. Cass

Research output: Contribution to journal › Article › peer-review

46 Scopus citations

Abstract

We have investigated methamphetamine (MA) toxicity in transgenic mice that overexpress the human form of mitochondrial manganese superoxide dismutase (MnSOD). Our results reveal a significant reduction in the long-term depletion of striatal dopamine and protein oxidation following repeated administration of MA in transgenic vs. non-transgenic littermates. These findings support the notion that ROS contribute to MA-induced brain damage and suggest that mitochondria may play an important role in this form of neurodegeneration. (C) 2000 Elsevier Science B.V.

Original language	English
Pages (from-to)	218-222
Number of pages	5
Journal	Brain Research
Volume	878
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(00)02707-4
State	Published - Sep 29 2000

Bibliographical note

Funding Information:
This work was supported by USPHS Grants NS 01941 to WFM, CA 59835 to DKS, DA 10115 to WAC and AG 10836 to DAB. Electron micrographs were obtained using the University of Kentucky’s Image Facility with the assistance of Ms. Mary Gail Engle.

Keywords

Dopamine
Manganese superoxide dismutase
Methamphetamine
Oxidative stress
Striatum
Transgenic mouse

ASJC Scopus subject areas

Neuroscience (all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(00)02707-4

Cite this

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title = "Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase",

abstract = "We have investigated methamphetamine (MA) toxicity in transgenic mice that overexpress the human form of mitochondrial manganese superoxide dismutase (MnSOD). Our results reveal a significant reduction in the long-term depletion of striatal dopamine and protein oxidation following repeated administration of MA in transgenic vs. non-transgenic littermates. These findings support the notion that ROS contribute to MA-induced brain damage and suggest that mitochondria may play an important role in this form of neurodegeneration. (C) 2000 Elsevier Science B.V.",

keywords = "Dopamine, Manganese superoxide dismutase, Methamphetamine, Oxidative stress, Striatum, Transgenic mouse",

author = "Maragos, {William F.} and Rebekah Jakel and Dathan Chesnut and Pocernich, {Chava B.} and Butterfield, {D. Allan} and {St Clair}, Daret and Cass, {Wayne A.}",

note = "Funding Information: This work was supported by USPHS Grants NS 01941 to WFM, CA 59835 to DKS, DA 10115 to WAC and AG 10836 to DAB. Electron micrographs were obtained using the University of Kentucky{\textquoteright}s Image Facility with the assistance of Ms. Mary Gail Engle.",

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doi = "10.1016/S0006-8993(00)02707-4",

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AU - Maragos, William F.

AU - Jakel, Rebekah

AU - Chesnut, Dathan

AU - Pocernich, Chava B.

AU - Butterfield, D. Allan

AU - St Clair, Daret

AU - Cass, Wayne A.

N1 - Funding Information: This work was supported by USPHS Grants NS 01941 to WFM, CA 59835 to DKS, DA 10115 to WAC and AG 10836 to DAB. Electron micrographs were obtained using the University of Kentucky’s Image Facility with the assistance of Ms. Mary Gail Engle.

PY - 2000/9/29

Y1 - 2000/9/29

N2 - We have investigated methamphetamine (MA) toxicity in transgenic mice that overexpress the human form of mitochondrial manganese superoxide dismutase (MnSOD). Our results reveal a significant reduction in the long-term depletion of striatal dopamine and protein oxidation following repeated administration of MA in transgenic vs. non-transgenic littermates. These findings support the notion that ROS contribute to MA-induced brain damage and suggest that mitochondria may play an important role in this form of neurodegeneration. (C) 2000 Elsevier Science B.V.

AB - We have investigated methamphetamine (MA) toxicity in transgenic mice that overexpress the human form of mitochondrial manganese superoxide dismutase (MnSOD). Our results reveal a significant reduction in the long-term depletion of striatal dopamine and protein oxidation following repeated administration of MA in transgenic vs. non-transgenic littermates. These findings support the notion that ROS contribute to MA-induced brain damage and suggest that mitochondria may play an important role in this form of neurodegeneration. (C) 2000 Elsevier Science B.V.

KW - Dopamine

KW - Manganese superoxide dismutase

KW - Methamphetamine

KW - Oxidative stress

KW - Striatum

KW - Transgenic mouse

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Methamphetamine toxicity is attenuated in mice that overexpress human manganese superoxide dismutase

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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