TY - JOUR
T1 - Methionine enkephalin is hydrolyzed by aminopeptidase N on CD4+ and CD8+ spleen T cells
AU - Miller, Bonnie C.
AU - Thiele, Dwain L.
AU - Hersh, Louis B.
AU - Larry Cottam, G.
PY - 1994/5
Y1 - 1994/5
N2 - Exogenous methionine enkephalin incubated with CD4+ or CD8+ T cells purified from murine spleen is metabolized primarily, if not exclusively, by aminopeptidase N (aminopeptidase M, EC 3.4.11.2), a membrane-anchored ectopeptidase. The enzyme activity is identified by its substrate specificity, sensitivity to inhibition by amastatin, and immunoreactivity with antibody to rat kidney aminopeptidase N. Activation of CD4+ T cells results in a small increase per cell in aminopeptidase N activity.
AB - Exogenous methionine enkephalin incubated with CD4+ or CD8+ T cells purified from murine spleen is metabolized primarily, if not exclusively, by aminopeptidase N (aminopeptidase M, EC 3.4.11.2), a membrane-anchored ectopeptidase. The enzyme activity is identified by its substrate specificity, sensitivity to inhibition by amastatin, and immunoreactivity with antibody to rat kidney aminopeptidase N. Activation of CD4+ T cells results in a small increase per cell in aminopeptidase N activity.
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U2 - 10.1006/abbi.1994.1223
DO - 10.1006/abbi.1994.1223
M3 - Article
C2 - 7910448
AN - SCOPUS:0028206327
SN - 0003-9861
VL - 311
SP - 174
EP - 179
JO - Archives of Biochemistry and Biophysics
JF - Archives of Biochemistry and Biophysics
IS - 1
ER -