Methodological issues in the assessment of neuropsychologic function after cardiac surgery

James A. Blumenthal, Elizabeth P. Mahanna, David J. Madden, William D. White, Narda D. Croughwell, Mark F. Newman

Research output: Contribution to journalArticlepeer-review

113 Scopus citations


This report reviews critical issues facing investigators interested in neuropsychologic sequelae after cardiac operations: (1) experimental design; (2) selective attrition; (3) selection of instruments; (4) moderating factors; (5) definitions of cognitive decline; (6) statistical analysis; and (7) clinical significance. Implications for further research in the area are discussed.

Original languageEnglish
Pages (from-to)1345-1350
Number of pages6
JournalAnnals of Thoracic Surgery
Issue number5
StatePublished - May 1995

Bibliographical note

Funding Information:
We thank Ms Catherine C. Craver, MEd, for assistance in the preparation of the manuscript. We also thank R. Lloyd Smith, PhD, for statistical advice; Carolina P. Clancy for assistance in neuropsychologic testing; Judy B. Lewis, BSN, and Connie C. Sessions, RN, for assistance in patient recruitment; and Joseph G. Reves, MD. This research was supported by grants, HL49572, AG09663, and MH49679 from the National Institutes of Health.

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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