Microbial-Derived Exerkines Prevent Skeletal Muscle Atrophy

Taylor R Valentino; Benjamin I Burke; Gyumin Kang; Jensen Goh; Cory M Dungan; Ahmed Ismaeel; C Brooks Mobley; Michael D Flythe; Yuan Wen; John J McCarthy

doi:10.1101/2024.05.29.596432

Microbial-Derived Exerkines Prevent Skeletal Muscle Atrophy

Taylor R Valentino, Benjamin I Burke, Gyumin Kang, Jensen Goh, Cory M Dungan, Ahmed Ismaeel, C Brooks Mobley, Michael D Flythe, Yuan Wen, John J McCarthy

Research output: Contribution to journal › Article

Abstract

Regular exercise yields a multitude of systemic benefits, many of which may be mediated through the gut microbiome. Here, we report that cecal microbial transplants (CMTs) from exercise-trained vs. sedentary mice have modest benefits in reducing skeletal muscle atrophy using a mouse model of unilaterally hindlimb-immobilization. Direct administration of top microbial-derived exerkines from an exercise-trained gut microbiome preserved muscle function and prevented skeletal muscle atrophy.

Original language	English
Journal	bioRxiv : the preprint server for biology
DOIs	https://doi.org/10.1101/2024.05.29.596432
State	Published - Jun 2 2024

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title = "Microbial-Derived Exerkines Prevent Skeletal Muscle Atrophy",

abstract = "Regular exercise yields a multitude of systemic benefits, many of which may be mediated through the gut microbiome. Here, we report that cecal microbial transplants (CMTs) from exercise-trained vs. sedentary mice have modest benefits in reducing skeletal muscle atrophy using a mouse model of unilaterally hindlimb-immobilization. Direct administration of top microbial-derived exerkines from an exercise-trained gut microbiome preserved muscle function and prevented skeletal muscle atrophy.",

author = "Valentino, {Taylor R} and Burke, {Benjamin I} and Gyumin Kang and Jensen Goh and Dungan, {Cory M} and Ahmed Ismaeel and Mobley, {C Brooks} and Flythe, {Michael D} and Yuan Wen and McCarthy, {John J}",

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doi = "10.1101/2024.05.29.596432",

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AU - Valentino, Taylor R

AU - Burke, Benjamin I

AU - Kang, Gyumin

AU - Goh, Jensen

AU - Dungan, Cory M

AU - Ismaeel, Ahmed

AU - Mobley, C Brooks

AU - Flythe, Michael D

AU - Wen, Yuan

AU - McCarthy, John J

PY - 2024/6/2

Y1 - 2024/6/2

N2 - Regular exercise yields a multitude of systemic benefits, many of which may be mediated through the gut microbiome. Here, we report that cecal microbial transplants (CMTs) from exercise-trained vs. sedentary mice have modest benefits in reducing skeletal muscle atrophy using a mouse model of unilaterally hindlimb-immobilization. Direct administration of top microbial-derived exerkines from an exercise-trained gut microbiome preserved muscle function and prevented skeletal muscle atrophy.

AB - Regular exercise yields a multitude of systemic benefits, many of which may be mediated through the gut microbiome. Here, we report that cecal microbial transplants (CMTs) from exercise-trained vs. sedentary mice have modest benefits in reducing skeletal muscle atrophy using a mouse model of unilaterally hindlimb-immobilization. Direct administration of top microbial-derived exerkines from an exercise-trained gut microbiome preserved muscle function and prevented skeletal muscle atrophy.

U2 - 10.1101/2024.05.29.596432

DO - 10.1101/2024.05.29.596432

M3 - Article

C2 - 38854012

SN - 2692-8205

JO - bioRxiv : the preprint server for biology

JF - bioRxiv : the preprint server for biology

ER -

Microbial-Derived Exerkines Prevent Skeletal Muscle Atrophy

Abstract

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