Microbial genome mining for accelerated natural products discovery: Is a renaissance in the making?

Brian O. Bachmann, Steven G. Van Lanen, Richard H. Baltz

Research output: Contribution to journalReview articlepeer-review

215 Scopus citations

Abstract

Microbial genome mining is a rapidly developing approach to discover new and novel secondary metabolites for drug discovery. Many advances have been made in the past decade to facilitate genome mining, and these are reviewed in this Special Issue of the Journal of Industrial Microbiology and Biotechnology. In this Introductory Review, we discuss the concept of genome mining and why it is important for the revitalization of natural product discovery; what microbes show the most promise for focused genome mining; how microbial genomes can be mined; how genome mining can be leveraged with other technologies; how progress on genome mining can be accelerated; and who should fund future progress in this promising field. We direct interested readers to more focused reviews on the individual topics in this Special Issue for more detailed summaries on the current state-of-the-art.

Original languageEnglish
Pages (from-to)175-184
Number of pages10
JournalJournal of Industrial Microbiology and Biotechnology
Volume41
Issue number2
DOIs
StatePublished - Feb 2014

Keywords

  • Combinatorial biosynthesis
  • Genome mining
  • Gifted microbes
  • Heterologous expression
  • Lasso peptides
  • NRPS
  • PKS
  • Secondary metabolite
  • Streptomyces

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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