Microcurrent electrotherapy improves palatal wound healing: Randomized clinical trial

Manuela Maria Viana Miguel, Ingrid Fernandes Mathias-Santamaria, Amanda Rossato, Laís Fernanda Ferreira Ferraz, Antônio Martins Figueiredo-Neto, Andrea Carvalho de Marco, Renato Corrêa Viana Casarin, Shannon Margaret Wallet, Dimitris N. Tatakis, Marcio Antonio Mathias, Mauro Pedrine Santamaria

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Background: This study was conducted to assess the clinical, immunological, and patient-centered outcomes of microcurrent electrotherapy on palatal wound healing. Methods: This was a parallel, double-masked randomized clinical trial, in which 53 patients with ridge preservation indications were selected and randomly assigned to one of two groups. In the control (sham) group (n = 27), palatal wounds, after free gingival grafts (FGG) harvest, received sham application of electrotherapy. In the test (electrotherapy treatment [EE]) group (n = 26), palatal wounds, after FGG harvest, received application of microcurrent electrotherapy protocol. Clinical parameters, patient-centered outcomes, and inflammatory markers were evaluated, up to 90 days postoperatively. Results: The EE group achieved earlier wound closure (P <0.001) and epithelialization (P <0.05; P = 0.03) at 7 and 14 days after harvest when compared with the sham group. Painful symptomatology was reported less frequently in the EE group than in the sham group at 3-day follow-up (P = 0.008). Likewise, an improvement in Oral Health Impact Profile was reported 2 days after the procedure by the EE group (P = 0.04). In addition, favorable modulation of inflammatory wound healing markers occurred when electrotherapy was applied. Conclusion: Within the limits of the present study, it can be concluded that the use of a low-intensity electrotherapy protocol may accelerate palatal wound healing and decrease patient discomfort after FGG harvest.

Original languageEnglish
Pages (from-to)244-253
Number of pages10
JournalJournal of Periodontology
Issue number2
StatePublished - Feb 2021

Bibliographical note

Publisher Copyright:
© 2020 American Academy of Periodontology


  • electric stimulation therapy
  • gingival recession
  • mucogingival surgery
  • wound healing

ASJC Scopus subject areas

  • Periodontics


Dive into the research topics of 'Microcurrent electrotherapy improves palatal wound healing: Randomized clinical trial'. Together they form a unique fingerprint.

Cite this