Microfabricated drug delivery devices

J. Zachary Hilt, Nicholas A. Peppas

Research output: Contribution to journalShort surveypeer-review

98 Scopus citations


We review newest developments in the design and fabrication of drug delivery devices based on micropatterned structures. Electronic devices have now reached a stage of dimensions comparable to those of biological macromolecules. This raises exciting possibilities for combining microelectronics and biotechnology to develop new technologies with unprecedented power and versatility. While molecular electronics use the unique self-assembly, switching and dynamic capabilities of molecules to miniaturize electronic devices, nanoscale biosystems use the power of microelectronics to design ultrafast/ultrasmall biocompatible devices, including implants, that can revolutionize the field of bioengineering. Thus, in recent years we have seen an explosion in the field of novel microfabricated and nanofabricated devices for drug delivery. Such devices seek to develop a platform of well controlled functions in the micro- or nano-level. They include nanoparticulate systems, recognitive molecular systems, biosensing devices, and microfabricated and microelectronic devices.

Original languageEnglish
Pages (from-to)15-23
Number of pages9
JournalInternational Journal of Pharmaceutics
Issue number1-2
StatePublished - Dec 8 2005

Bibliographical note

Funding Information:
Work from our laboratory reported here was supported by National Science Foundation grants CTS-03-29317 and DGE-03-33080 and National Institutes of Health grant EB000246-13A.


  • Drug delivery
  • Microdevice
  • Microfabrication
  • Microneedle

ASJC Scopus subject areas

  • Pharmaceutical Science


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