TY - JOUR
T1 - Microglia as drivers of neurodegeneration
T2 - The role of innate-adaptive immune signaling
AU - Kumari, Reena
AU - Gensel, John C.
N1 - Publisher Copyright:
© 2023 Elsevier Inc.
PY - 2023/3/1
Y1 - 2023/3/1
N2 - Microglia contribute to neurodegeneration through numerous mechanisms. In this issue of Neuron, Shi et al.1 identify a maladaptive innate-adaptive immune axis with CD8+ T cells, mediated through microglial CCL2/8 and CCR2/5, in radiation-induced brain injury and stroke. Their findings across species and injuries suggest broader implications for neurodegenerative conditions.
AB - Microglia contribute to neurodegeneration through numerous mechanisms. In this issue of Neuron, Shi et al.1 identify a maladaptive innate-adaptive immune axis with CD8+ T cells, mediated through microglial CCL2/8 and CCR2/5, in radiation-induced brain injury and stroke. Their findings across species and injuries suggest broader implications for neurodegenerative conditions.
UR - http://www.scopus.com/inward/record.url?scp=85148759471&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85148759471&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2023.02.005
DO - 10.1016/j.neuron.2023.02.005
M3 - Comment/debate
C2 - 36863316
AN - SCOPUS:85148759471
SN - 0896-6273
VL - 111
SP - 597
EP - 598
JO - Neuron
JF - Neuron
IS - 5
ER -