Microglia as drivers of neurodegeneration: The role of innate-adaptive immune signaling

Reena Kumari; John C. Gensel

doi:10.1016/j.neuron.2023.02.005

Microglia as drivers of neurodegeneration: The role of innate-adaptive immune signaling

Research output: Contribution to journal › Comment/debate

Abstract

Microglia contribute to neurodegeneration through numerous mechanisms. In this issue of Neuron, Shi et al.¹ identify a maladaptive innate-adaptive immune axis with CD8⁺ T cells, mediated through microglial CCL2/8 and CCR2/5, in radiation-induced brain injury and stroke. Their findings across species and injuries suggest broader implications for neurodegenerative conditions.

Original language	English
Pages (from-to)	597-598
Number of pages	2
Journal	Neuron
Volume	111
Issue number	5
DOIs	https://doi.org/10.1016/j.neuron.2023.02.005
State	Published - Mar 1 2023

Bibliographical note

Funding Information:
The authors declare no conflicts of interest.

Publisher Copyright:
© 2023 Elsevier Inc.

ASJC Scopus subject areas

Neuroscience (all)

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10.1016/j.neuron.2023.02.005

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title = "Microglia as drivers of neurodegeneration: The role of innate-adaptive immune signaling",

abstract = "Microglia contribute to neurodegeneration through numerous mechanisms. In this issue of Neuron, Shi et al.1 identify a maladaptive innate-adaptive immune axis with CD8+ T cells, mediated through microglial CCL2/8 and CCR2/5, in radiation-induced brain injury and stroke. Their findings across species and injuries suggest broader implications for neurodegenerative conditions.",

author = "Reena Kumari and Gensel, {John C.}",

note = "Funding Information: The authors declare no conflicts of interest. Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",

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AB - Microglia contribute to neurodegeneration through numerous mechanisms. In this issue of Neuron, Shi et al.1 identify a maladaptive innate-adaptive immune axis with CD8+ T cells, mediated through microglial CCL2/8 and CCR2/5, in radiation-induced brain injury and stroke. Their findings across species and injuries suggest broader implications for neurodegenerative conditions.

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Microglia as drivers of neurodegeneration: The role of innate-adaptive immune signaling

Abstract

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