Microglia as drivers of neurodegeneration: The role of innate-adaptive immune signaling

Reena Kumari, John C. Gensel

Research output: Contribution to journalComment/debate

1 Scopus citations

Abstract

Microglia contribute to neurodegeneration through numerous mechanisms. In this issue of Neuron, Shi et al.1 identify a maladaptive innate-adaptive immune axis with CD8+ T cells, mediated through microglial CCL2/8 and CCR2/5, in radiation-induced brain injury and stroke. Their findings across species and injuries suggest broader implications for neurodegenerative conditions.

Original languageEnglish
Pages (from-to)597-598
Number of pages2
JournalNeuron
Volume111
Issue number5
DOIs
StatePublished - Mar 1 2023

Bibliographical note

Publisher Copyright:
© 2023 Elsevier Inc.

ASJC Scopus subject areas

  • General Neuroscience

Fingerprint

Dive into the research topics of 'Microglia as drivers of neurodegeneration: The role of innate-adaptive immune signaling'. Together they form a unique fingerprint.

Cite this