MicroRNA-206: The skeletal muscle-specific myomiR

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344 Scopus citations

Abstract

MicroRNAs (miRNAs) are a class of non-coding RNAs involved in post-transcriptional gene silencing. A small number of striated muscle-specific miRNAs have been identified and shown to have an important role in myogenesis, embryonic muscle growth and cardiac function and hypertrophy. One of these myomiRs (myo = muscle + miR = miRNA), miR-206, is unique in that it is only expressed in skeletal muscle. The purpose of this review is to discuss what is currently known about miR-206 and its function in myogenesis as well as propose potential new roles for miR-206 in skeletal muscle biology. The review is also intended to serve as a comprehensive resource for miR-206 with the hope of encouraging further research on the role of miR-206 in skeletal muscle.

Original languageEnglish
Pages (from-to)682-691
Number of pages10
JournalBiochimica et Biophysica Acta - Gene Regulatory Mechanisms
Volume1779
Issue number11
DOIs
StatePublished - Nov 2008

Bibliographical note

Funding Information:
I would like to thank Drs. Esser, Andrade and Shroeder for their careful reading of the manuscript. A special thanks to Dr. Sempere for providing raw data and insightful comments on the manuscript. This publication was made possible by grants from NIAMS/NIH to JJM (AR053641) and KAE (AR45617).

Keywords

  • Circadian
  • Fiber-type
  • MicroRNA
  • Satellite cell
  • Skeletal muscle

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics

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