Abstract
MicroRNAs (miRNAs) are a class of non-coding RNAs involved in post-transcriptional gene silencing. A small number of striated muscle-specific miRNAs have been identified and shown to have an important role in myogenesis, embryonic muscle growth and cardiac function and hypertrophy. One of these myomiRs (myo = muscle + miR = miRNA), miR-206, is unique in that it is only expressed in skeletal muscle. The purpose of this review is to discuss what is currently known about miR-206 and its function in myogenesis as well as propose potential new roles for miR-206 in skeletal muscle biology. The review is also intended to serve as a comprehensive resource for miR-206 with the hope of encouraging further research on the role of miR-206 in skeletal muscle.
| Original language | English |
|---|---|
| Pages (from-to) | 682-691 |
| Number of pages | 10 |
| Journal | Biochimica et Biophysica Acta - Gene Regulatory Mechanisms |
| Volume | 1779 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 2008 |
Bibliographical note
Funding Information:I would like to thank Drs. Esser, Andrade and Shroeder for their careful reading of the manuscript. A special thanks to Dr. Sempere for providing raw data and insightful comments on the manuscript. This publication was made possible by grants from NIAMS/NIH to JJM (AR053641) and KAE (AR45617).
Keywords
- Circadian
- Fiber-type
- MicroRNA
- Satellite cell
- Skeletal muscle
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics