MicroRNA-206: The skeletal muscle-specific myomiR

John J. McCarthy

doi:10.1016/j.bbagrm.2008.03.001

MicroRNA-206: The skeletal muscle-specific myomiR

John J. McCarthy

Physiology

Research output: Contribution to journal › Review article › peer-review

373 Scopus citations

Abstract

MicroRNAs (miRNAs) are a class of non-coding RNAs involved in post-transcriptional gene silencing. A small number of striated muscle-specific miRNAs have been identified and shown to have an important role in myogenesis, embryonic muscle growth and cardiac function and hypertrophy. One of these myomiRs (myo = muscle + miR = miRNA), miR-206, is unique in that it is only expressed in skeletal muscle. The purpose of this review is to discuss what is currently known about miR-206 and its function in myogenesis as well as propose potential new roles for miR-206 in skeletal muscle biology. The review is also intended to serve as a comprehensive resource for miR-206 with the hope of encouraging further research on the role of miR-206 in skeletal muscle.

Original language	English
Pages (from-to)	682-691
Number of pages	10
Journal	Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
Volume	1779
Issue number	11
DOIs	https://doi.org/10.1016/j.bbagrm.2008.03.001
State	Published - Nov 2008

Bibliographical note

Funding Information:
I would like to thank Drs. Esser, Andrade and Shroeder for their careful reading of the manuscript. A special thanks to Dr. Sempere for providing raw data and insightful comments on the manuscript. This publication was made possible by grants from NIAMS/NIH to JJM (AR053641) and KAE (AR45617).

Funding

I would like to thank Drs. Esser, Andrade and Shroeder for their careful reading of the manuscript. A special thanks to Dr. Sempere for providing raw data and insightful comments on the manuscript. This publication was made possible by grants from NIAMS/NIH to JJM (AR053641) and KAE (AR45617).

Funders	Funder number
National Institutes of Health (NIH)	AR053641
National Institute of Arthritis and Musculoskeletal and Skin Diseases	R01AR045617

Keywords

Circadian
Fiber-type
MicroRNA
Satellite cell
Skeletal muscle

ASJC Scopus subject areas

Biophysics
Structural Biology
Biochemistry
Molecular Biology
Genetics

Access to Document

10.1016/j.bbagrm.2008.03.001

Cite this

@article{e13f512388df43fcb272556eafd11995,

title = "MicroRNA-206: The skeletal muscle-specific myomiR",

abstract = "MicroRNAs (miRNAs) are a class of non-coding RNAs involved in post-transcriptional gene silencing. A small number of striated muscle-specific miRNAs have been identified and shown to have an important role in myogenesis, embryonic muscle growth and cardiac function and hypertrophy. One of these myomiRs (myo = muscle + miR = miRNA), miR-206, is unique in that it is only expressed in skeletal muscle. The purpose of this review is to discuss what is currently known about miR-206 and its function in myogenesis as well as propose potential new roles for miR-206 in skeletal muscle biology. The review is also intended to serve as a comprehensive resource for miR-206 with the hope of encouraging further research on the role of miR-206 in skeletal muscle.",

keywords = "Circadian, Fiber-type, MicroRNA, Satellite cell, Skeletal muscle",

author = "McCarthy, \{John J.\}",

note = "Funding Information: I would like to thank Drs. Esser, Andrade and Shroeder for their careful reading of the manuscript. A special thanks to Dr. Sempere for providing raw data and insightful comments on the manuscript. This publication was made possible by grants from NIAMS/NIH to JJM (AR053641) and KAE (AR45617). ",

year = "2008",

month = nov,

doi = "10.1016/j.bbagrm.2008.03.001",

language = "English",

volume = "1779",

pages = "682--691",

number = "11",

}

TY - JOUR

T1 - MicroRNA-206

T2 - The skeletal muscle-specific myomiR

AU - McCarthy, John J.

N1 - Funding Information: I would like to thank Drs. Esser, Andrade and Shroeder for their careful reading of the manuscript. A special thanks to Dr. Sempere for providing raw data and insightful comments on the manuscript. This publication was made possible by grants from NIAMS/NIH to JJM (AR053641) and KAE (AR45617).

PY - 2008/11

Y1 - 2008/11

N2 - MicroRNAs (miRNAs) are a class of non-coding RNAs involved in post-transcriptional gene silencing. A small number of striated muscle-specific miRNAs have been identified and shown to have an important role in myogenesis, embryonic muscle growth and cardiac function and hypertrophy. One of these myomiRs (myo = muscle + miR = miRNA), miR-206, is unique in that it is only expressed in skeletal muscle. The purpose of this review is to discuss what is currently known about miR-206 and its function in myogenesis as well as propose potential new roles for miR-206 in skeletal muscle biology. The review is also intended to serve as a comprehensive resource for miR-206 with the hope of encouraging further research on the role of miR-206 in skeletal muscle.

AB - MicroRNAs (miRNAs) are a class of non-coding RNAs involved in post-transcriptional gene silencing. A small number of striated muscle-specific miRNAs have been identified and shown to have an important role in myogenesis, embryonic muscle growth and cardiac function and hypertrophy. One of these myomiRs (myo = muscle + miR = miRNA), miR-206, is unique in that it is only expressed in skeletal muscle. The purpose of this review is to discuss what is currently known about miR-206 and its function in myogenesis as well as propose potential new roles for miR-206 in skeletal muscle biology. The review is also intended to serve as a comprehensive resource for miR-206 with the hope of encouraging further research on the role of miR-206 in skeletal muscle.

KW - Circadian

KW - Fiber-type

KW - MicroRNA

KW - Satellite cell

KW - Skeletal muscle

UR - https://www.scopus.com/pages/publications/55249117284

UR - https://www.scopus.com/pages/publications/55249117284#tab=citedBy

U2 - 10.1016/j.bbagrm.2008.03.001

DO - 10.1016/j.bbagrm.2008.03.001

M3 - Review article

C2 - 18381085

AN - SCOPUS:55249117284

SN - 1874-9399

VL - 1779

SP - 682

EP - 691

JO - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

JF - Biochimica et Biophysica Acta - Gene Regulatory Mechanisms

IS - 11

ER -

MicroRNA-206: The skeletal muscle-specific myomiR

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this