Micrornas as biomarkers for predicting complications following aneurysmal subarachnoid hemorrhage

Wang Xia Wang, Joe E. Springer, Kevin W. Hatton

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations

Abstract

Aneurysmal subarachnoid hemorrhage (aSAH) is a high mortality hemorrhagic stroke that affects nearly 30,000 patients annually in the United States. Approximately 30% of aSAH patients die during initial hospitalization and those who survive often carry poor prognosis with one in five having permanent physical and/or cognitive disabilities. The poor outcome of aSAH can be the result of the initial catastrophic event or due to the many acute or delayed neurological complications, such as cerebral ischemia, hydrocephalus, and re-bleeding. Unfortunately, no effective biomarker exists to predict or diagnose these complications at a clinically relevant time point when neurologic injury can be effectively treated and managed. Recently, a number of studies have demonstrated that microRNAs (miRNAs) in extracellular biofluids are highly associated with aSAH and complications. Here we provide an overview of the current research on relevant human studies examining the correlation between miRNAs and aSAH complications and discuss the potential application of using miRNAs as biomarkers in aSAH management.

Original languageEnglish
Article number9492
JournalInternational Journal of Molecular Sciences
Volume22
Issue number17
DOIs
StatePublished - Sep 1 2021

Bibliographical note

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Aneurysmal subarachnoid hemorrhage
  • Biofluid
  • Biomarker
  • Delay cerebral ischemia
  • Delayed cerebral vasospasm
  • MicroRNA

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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