MicroRNAs, heart failure, and aging: potential interactions with skeletal muscle

Kevin A. Murach, John J. McCarthy

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression by targeting mRNAs for degradation or translational repression. MiRNAs can be expressed tissue specifically and are altered in response to various physiological conditions. It has recently been shown that miRNAs are released into the circulation, potentially for the purpose of communicating with distant tissues. This manuscript discusses miRNA alterations in cardiac muscle and the circulation during heart failure, a prevalent and costly public health issue. A potential mechanism for how skeletal muscle maladaptations during heart failure could be mediated by myocardium-derived miRNAs released to the circulation is presented. An overview of miRNA alterations in skeletal muscle during the ubiquitous process of aging and perspectives on miRNA interactions during heart failure are also provided.

Original languageEnglish
Pages (from-to)209-218
Number of pages10
JournalHeart Failure Reviews
Issue number2
StatePublished - Mar 1 2017

Bibliographical note

Publisher Copyright:
© 2016, Springer Science+Business Media New York.


  • Aging
  • Exosomes
  • Heart failure
  • MicroRNA
  • Skeletal muscle

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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