Abstract
MicroRNAs (miRNAs) are small endogenous non-coding molecules that alters gene expression through post-transcriptional regulation of messenger RNA. Compelling evidence suggest the role of miRNA in cancer biology having potential as diagnostic, prognostic and predictive biomarkers. This review summarizes the current knowledge on miRNA deregulated in prostate cancer and their role as oncogene, tumor suppressor and metastasis regulators. The emerging information elucidating the biological function of miRNA is promising and may lead to their potential usefulness as diagnostic/prognostic markers and development as effective therapeutic tools for management of prostate cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 9-20 |
| Number of pages | 12 |
| Journal | Cancer Letters |
| Volume | 407 |
| DOIs | |
| State | Published - Oct 28 2017 |
Bibliographical note
Publisher Copyright:© 2017 Elsevier B.V.
Funding
The research work in SG lab is supported by United States Public Health Service Grant R01CA108512 , R21CA193080 , R03CA186179 , VA Merit Award 1I01BX002494 and Department of Defense grant W81XWH-15-1-0558 . Research in GCS lab is supported by Department of Defense grants W81XWH-14-1-0508 and W81XWH-14-1-0509 . The research work cited was partially supported by Faculty Research Development Grant of Cleveland State University and Center for Gene Regulation in Health and Disease grant.
| Funders | Funder number |
|---|---|
| U.S. Department of Defense | W81XWH-15-1-0558, W81XWH-14-1-0509, W81XWH-14-1-0508 |
| Cleveland State University | |
| U.S. Public Health Service | 1I01BX002494, R01CA108512, R21CA193080, R03CA186179 |
| Faculty of Arts and Sciences, Harvard University |
Keywords
- Androgen receptor
- Biomarkers
- Castrate-resistant prostate cancer
- Non-coding RNA
- Oncomirs
- Tumor suppressor
ASJC Scopus subject areas
- Oncology
- Cancer Research
