MicroRNAs in prostate cancer: Functional role as biomarkers

Rajnee Kanwal; Alexis R. Plaga; Xiaoqi Liu; Girish C. Shukla; Sanjay Gupta

doi:10.1016/j.canlet.2017.08.011

MicroRNAs in prostate cancer: Functional role as biomarkers

Rajnee Kanwal, Alexis R. Plaga, Xiaoqi Liu, Girish C. Shukla, Sanjay Gupta

Research output: Contribution to journal › Review article › peer-review

132 Scopus citations

Abstract

MicroRNAs (miRNAs) are small endogenous non-coding molecules that alters gene expression through post-transcriptional regulation of messenger RNA. Compelling evidence suggest the role of miRNA in cancer biology having potential as diagnostic, prognostic and predictive biomarkers. This review summarizes the current knowledge on miRNA deregulated in prostate cancer and their role as oncogene, tumor suppressor and metastasis regulators. The emerging information elucidating the biological function of miRNA is promising and may lead to their potential usefulness as diagnostic/prognostic markers and development as effective therapeutic tools for management of prostate cancer.

Original language	English
Pages (from-to)	9-20
Number of pages	12
Journal	Cancer Letters
Volume	407
DOIs	https://doi.org/10.1016/j.canlet.2017.08.011
State	Published - Oct 28 2017

Bibliographical note

Publisher Copyright:
© 2017 Elsevier B.V.

Keywords

Androgen receptor
Biomarkers
Castrate-resistant prostate cancer
Non-coding RNA
Oncomirs
Tumor suppressor

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.canlet.2017.08.011

Cite this

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title = "MicroRNAs in prostate cancer: Functional role as biomarkers",

abstract = "MicroRNAs (miRNAs) are small endogenous non-coding molecules that alters gene expression through post-transcriptional regulation of messenger RNA. Compelling evidence suggest the role of miRNA in cancer biology having potential as diagnostic, prognostic and predictive biomarkers. This review summarizes the current knowledge on miRNA deregulated in prostate cancer and their role as oncogene, tumor suppressor and metastasis regulators. The emerging information elucidating the biological function of miRNA is promising and may lead to their potential usefulness as diagnostic/prognostic markers and development as effective therapeutic tools for management of prostate cancer.",

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year = "2017",

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doi = "10.1016/j.canlet.2017.08.011",

language = "English",

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T1 - MicroRNAs in prostate cancer

T2 - Functional role as biomarkers

AU - Kanwal, Rajnee

AU - Plaga, Alexis R.

AU - Liu, Xiaoqi

AU - Shukla, Girish C.

AU - Gupta, Sanjay

PY - 2017/10/28

Y1 - 2017/10/28

N2 - MicroRNAs (miRNAs) are small endogenous non-coding molecules that alters gene expression through post-transcriptional regulation of messenger RNA. Compelling evidence suggest the role of miRNA in cancer biology having potential as diagnostic, prognostic and predictive biomarkers. This review summarizes the current knowledge on miRNA deregulated in prostate cancer and their role as oncogene, tumor suppressor and metastasis regulators. The emerging information elucidating the biological function of miRNA is promising and may lead to their potential usefulness as diagnostic/prognostic markers and development as effective therapeutic tools for management of prostate cancer.

AB - MicroRNAs (miRNAs) are small endogenous non-coding molecules that alters gene expression through post-transcriptional regulation of messenger RNA. Compelling evidence suggest the role of miRNA in cancer biology having potential as diagnostic, prognostic and predictive biomarkers. This review summarizes the current knowledge on miRNA deregulated in prostate cancer and their role as oncogene, tumor suppressor and metastasis regulators. The emerging information elucidating the biological function of miRNA is promising and may lead to their potential usefulness as diagnostic/prognostic markers and development as effective therapeutic tools for management of prostate cancer.

KW - Androgen receptor

KW - Biomarkers

KW - Castrate-resistant prostate cancer

KW - Non-coding RNA

KW - Oncomirs

KW - Tumor suppressor

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U2 - 10.1016/j.canlet.2017.08.011

DO - 10.1016/j.canlet.2017.08.011

M3 - Review article

C2 - 28823964

AN - SCOPUS:85028074344

SN - 0304-3835

VL - 407

SP - 9

EP - 20

JO - Cancer Letters

JF - Cancer Letters

ER -

MicroRNAs in prostate cancer: Functional role as biomarkers

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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