TY - JOUR
T1 - MicroRNAs in skeletal muscle biology and exercise adaptation
AU - Kirby, Tyler J.
AU - McCarthy, John J.
PY - 2013
Y1 - 2013
N2 - MicroRNAs (miRNAs) have emerged as important players in the regulation of gene expression, being involved in most biological processes examined to date. The proposal that miRNAs are primarily involved in the stress response of the cell makes miRNAs ideally suited to mediate the response of skeletal muscle to changes in contractile activity. Although the field is still in its infancy, the studies presented in this review highlight the promise that miRNAs will have an important role in mediating the response and adaptation of skeletal muscle to various modes of exercise. The roles of miRNAs in satellite cell biology, muscle regeneration, and various myopathies are also discussed.
AB - MicroRNAs (miRNAs) have emerged as important players in the regulation of gene expression, being involved in most biological processes examined to date. The proposal that miRNAs are primarily involved in the stress response of the cell makes miRNAs ideally suited to mediate the response of skeletal muscle to changes in contractile activity. Although the field is still in its infancy, the studies presented in this review highlight the promise that miRNAs will have an important role in mediating the response and adaptation of skeletal muscle to various modes of exercise. The roles of miRNAs in satellite cell biology, muscle regeneration, and various myopathies are also discussed.
KW - Exercise
KW - Free radicals
KW - MicroRNA
KW - MyomiR
KW - Skeletal muscle
UR - http://www.scopus.com/inward/record.url?scp=84885179745&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84885179745&partnerID=8YFLogxK
U2 - 10.1016/j.freeradbiomed.2013.07.004
DO - 10.1016/j.freeradbiomed.2013.07.004
M3 - Review article
C2 - 23872025
AN - SCOPUS:84885179745
SN - 0891-5849
VL - 64
SP - 95
EP - 105
JO - Free Radical Biology and Medicine
JF - Free Radical Biology and Medicine
ER -