Midline Spikes: EEG and Clinical Features

Kevin R. Nelson, Richard P. Brenner, Daniel Paz

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Clinical features of 40 patients with midline spikes on EEG were compared with those of age- and sex-matched controls. Seizure incidence was significantly greater in the study group than in the controls (85% v 45%). Tonic-clonic seizures were the most frequent type. Eighteen patients from the study group had additional focal or generalized epileptiform abnormalities. This subgroup had a significantly greater incidence of seizures than patients with only midline spikes (100% v 73%). Midline spikes are more common in children and markedly activated with sleep. They must be distinguished from normal sleep transients.

Original languageEnglish
Pages (from-to)473-476
Number of pages4
JournalArchives of Neurology
Issue number8
StatePublished - Aug 1983

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology


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