Abstract
We report a mild method for the selective deprotection of the N-Boc group from a structurally diverse set of compounds, encompassing aliphatic, aromatic, and heterocyclic substrates by using oxalyl chloride in methanol. The reactions take place under room temperature conditions for 1-4 h with yields up to 90%. This mild procedure was applied to a hybrid, medicinally active compound FC1, which is a novel dual inhibitor of IDO1 and DNA Pol gamma. A broader mechanism involving the electrophilic character of oxalyl chloride is postulated for this deprotection strategy.
Original language | English |
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Pages (from-to) | 24017-24026 |
Number of pages | 10 |
Journal | RSC Advances |
Volume | 10 |
Issue number | 40 |
DOIs | |
State | Published - Jun 23 2020 |
Bibliographical note
Publisher Copyright:© The Royal Society of Chemistry.
ASJC Scopus subject areas
- General Chemistry
- General Chemical Engineering