Milk intake at midlife and cognitive decline over 20 years. The atherosclerosis risk in communities (ARIC) study

Natalia Petruski-Ivleva, Anna Kucharska-Newton, Priya Palta, David Couper, Katie Meyer, Misa Graff, Bernhard Haring, Richey Sharrett, Gerardo Heiss

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Background: Faster rates of cognitive decline are likely to result in earlier onset of cognitive impairment and dementia.D-galactose, a derivative of lactose, is used in animal studies to induce neurodegeneration. Milk is the primary source of lactose in the human diet, and its effects on cognitive decline have not been fully evaluated. Objective: Assess the association of milk intake with change in cognitive function over 20 years. Methods: A total of 13,751 participants of the Atherosclerosis Risk in Communities (ARIC) cohort completed a food frequency questionnaire and three neurocognitive evaluations from 1990 through 2013. Two single nucleotide polymorphisms (SNPs) were used to determine lactase persistence (LCT-13910 C/T for Whites and LCT-14010 G/C for Blacks). Mixed-effects models were used to study the association of milk intake with cognitive change. Multiple imputations by chained equations were used to account for attrition. Results: Milk intake greater than 1 glass/day was associated with greater decline in the global z-score over a 20-year period. The difference in decline was 0.10 (95% CI: 0.16, 0.03) z-scores, or an additional 10% decline, relative to the group reporting “almost never” consuming milk. Conclusions: Replication of these results is warranted in diverse populations with greater milk intake and higher variability of lactase persistence genotype.

Original languageEnglish
Article number1134
Issue number10
StatePublished - Oct 17 2017

Bibliographical note

Funding Information:
Acknowledgments: The Atherosclerosis Risk in Communities Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts (HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, and HHSN268201100012C). Neurocognitive data is collected by U01 HL096812, HL096814, HL096899, HL096902, HL096917 with previous brain MRI examinations funded by R01-HL70825. The authors thank the staff and participants of the ARIC study for their important contributions.

Publisher Copyright:
© 2017 by the authors. Licensee MDPI, Basel, Switzerland.


  • Aging
  • Cognitive decline
  • Dementia
  • Lactase persistence
  • Lactose
  • Oxidative stress

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics


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