MiR-107 is reduced in Alzheimer's disease brain neocortex: Validation study

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188 Scopus citations


MiR-107 is a microRNA (miRNA) that we reported previously to have decreased expression in the temporal cortical gray matter early in the progression of Alzheimer's disease (AD). Here we study a new group of well-characterized human temporal cortex samples (N=19). MiR-107 expression was assessed, normalized to miR-124 and let-7a. Correlation was observed between decreased miR-107 expression and increased neuritic plaque counts (P< 0.05) and neurofibrillary tangle counts (P< 0.02) in adjacent brain tissue. Adjusted miR-107 and BACE1 mRNA levels tended to correlate negatively (trend with regression P< 0.07). In sum, miR-107 expression tends to be lower relative to other miRNAs as AD progresses.

Original languageEnglish
Pages (from-to)75-79
Number of pages5
JournalJournal of Alzheimer's Disease
Issue number1
StatePublished - 2010


  • Amyloid
  • RTqPCR
  • metabolism
  • neurodegeneration
  • noncoding
  • tau

ASJC Scopus subject areas

  • Neuroscience (all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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