MiR-205 dysregulations in breast cancer: The complexity and opportunities

Yajuan Xiao, Brock Humphries, Chengfeng Yang, Zhishan Wang

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations

Abstract

MicroRNAs (miRNAs) are endogenous non-coding small RNAs that downregulate target gene expression by imperfect base-pairing with the 3′ untranslated regions (3′UTRs) of target gene mRNAs. MiRNAs play important roles in regulating cancer cell proliferation, stemness maintenance, tumorigenesis, cancer metastasis, and cancer therapeutic resistance. While studies have shown that dysregulation of miRNA-205-5p (miR-205) expression is controversial in dierent types of human cancers, it is generally observed that miR-205-5p expression level is downregulated in breast cancer and that miR-205-5p exhibits a tumor suppressive function in breast cancer. This review focuses on the role of miR-205-5p dysregulation in dierent subtypes of breast cancer, with discussions on the eects of miR-205-5p on breast cancer cell proliferation, epithelial-mesenchymal transition (EMT), metastasis, stemness and therapy-resistance, as well as genetic and epigenetic mechanisms that regulate miR-205-5p expression in breast cancer. In addition, the potential diagnostic and therapeutic value of miR-205-5p in breast cancer is also discussed. A comprehensive list of validated miR-205-5p direct targets is presented. It is concluded that miR-205-5p is an important tumor suppressive miRNA capable of inhibiting the growth and metastasis of human breast cancer, especially triple negative breast cancer. MiR-205-5p might be both a potential diagnostic biomarker and a therapeutic target for metastatic breast cancer.

Original languageEnglish
Article number53
JournalNon-coding RNA
Volume5
Issue number4
DOIs
StatePublished - Dec 1 2019

Bibliographical note

Funding Information:
This work was supported by a Research Scholar Grant (RGS-15-026-01-CSM) from the American Cancer Society, and a Postdoctoral Fellowship (PF-18-236-01-CCG) from the American Cancer Society-Michigan Cancer Research Fund.

Publisher Copyright:
© 2019 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • Breast cancer
  • Her2 breast cancer
  • Luminal A/B breast cancer
  • Metastatic breast cancer
  • Triple negative breast cancer
  • miR-205-5p (miR-205)

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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