Mitochondria focused neurotherapeutics for spinal cord injury

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

The mitochondrion is a double membrane structured organelle involved in a variety of regulatory functions such as calcium signaling, production of adenosine triphosphate, apoptosis, reactive oxygen species generation, cell growth, and cell cycling. Impaired mitochondrial function is evident in various neurological disorders stemming from both acute and chronic neural injury. Herein, we review the role of mitochondrial regulation in maintaining cellular homeostasis, the consequences of their dysfunction in relation to pathophysiology after neurotrauma, approaches being used to promote their bioenergetic integrity for neuroprotection, and multifaceted methods being used to preserve/rescue their function following both traumatic brain and spinal cord injury.

Original languageEnglish
Article number113332
JournalExperimental Neurology
Volume330
DOIs
StatePublished - Aug 2020

Bibliographical note

Funding Information:
Financial Support: An endowment from the Spinal Cord & Brain Injury Research Center, University of Kentucky (AGR). This sponsor did not contribute to the preparation of this manuscript.

Publisher Copyright:
© 2020 Elsevier Inc.

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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