Mitochondrial death effectors: Relevance to sarcopenia and disuse muscle atrophy

Emanuele Marzetti, Judy C.Y. Hwang, Hazel A. Lees, Stephanie E. Wohlgemuth, Esther E. Dupont-Versteegden, Christy S. Carter, Roberto Bernabei, Christiaan Leeuwenburgh

Research output: Contribution to journalReview articlepeer-review

150 Scopus citations


Accelerated apoptosis in skeletal muscle is increasingly recognized as a potential mechanism contributing to the development of sarcopenia of aging and disuse muscle atrophy. Given their central role in the regulation of apoptosis, mitochondria are regarded as key players in the pathogenesis of myocyte loss during aging and other atrophying conditions. Oxidative damage to mitochondrial constituents, impaired respiration and altered mitochondrial turnover have been proposed as potential triggering events for mitochondrial apoptotic signaling. In addition, iron accumulation within mitochondria may enhance the susceptibility to apoptosis during the development of sarcopenia and possibly acute muscle atrophy, likely through exacerbation of oxidative stress. Mitochondria can induce myocyte apoptosis via both caspase-dependent and independent pathways, although the apoptogenic mediators involved may be different depending on age, muscle type and specific atrophying conditions. Despite the considerable advances made, additional research is necessary to establish a definite causal link between apoptotic signaling and the development of sarcopenia and acute atrophy. Furthermore, a translational effort is required to determine the role played by apoptosis in the pathogenesis of sarcopenia and disuse-induced muscle loss in human subjects.

Original languageEnglish
Pages (from-to)235-244
Number of pages10
JournalBiochimica et Biophysica Acta - General Subjects
Issue number3
StatePublished - Mar 2010


  • Apoptosis
  • Apoptosis-inducing factor
  • Caspases
  • Endonuclease G
  • Iron
  • Mitochondria
  • Muscle atrophy
  • Sarcopenia

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology


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