Mitochondrial drug delivery systems

W. Brad Hubbard, Hemendra J. Vekaria, Patrick G. Sullivan

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

2 Scopus citations

Abstract

Mitochondrial dysfunction is a hallmark pathological process of multiple neurodegenerative diseases (NDs). This chapter will highlight mitochondrial dysfunction and therapeutic approaches to restore mitochondrial bioenergetics in NDs. There is a distinct focus on drug delivery systems that have unique pharmacokinetic signatures or novel formulations that can have advantages in translation. After introducing distinct deficits in mitochondrial function unique to each ND, we will highlight mitochondrial drug delivery approaches that target mitochondria through mechanisms of oxidative stress, mitochondrial membrane potential, mitochondrial permeability transition pore, mitochondrial-induced apoptosis, biofuel deficiency, and mitochondrial dynamics. Completed clinical trials will be discussed throughout, and promising new mitochondrial-targeted strategies will be proposed.

Original languageEnglish
Title of host publicationClinical Bioenergetics
Subtitle of host publicationFrom Pathophysiology to Clinical Translation
Pages385-409
Number of pages25
ISBN (Electronic)9780128196212
DOIs
StatePublished - Jan 1 2020

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Inc. All rights reserved.

Keywords

  • Alzheimer’s disease
  • Calcium
  • Cyclosporine A
  • Dinitrophenol
  • Huntington’s disease
  • Mitochondrial biogenesis
  • Mitochondrial dynamics
  • Oxidative stress
  • Parkinson’s disease
  • Traumatic brain injury

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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