Mitochondrial transplantation strategies as potential therapeutics for central nervous system trauma

Jenna L. Gollihue; Samir P. Patel; Alexander G. Rabchevsky

doi:10.4103/1673-5374.226382

Mitochondrial transplantation strategies as potential therapeutics for central nervous system trauma

Jenna L. Gollihue, Samir P. Patel, Alexander G. Rabchevsky

Research output: Contribution to journal › Review article › peer-review

31 Scopus citations

Abstract

Mitochondria are essential cellular organelles critical for generating adenosine triphosphate for cellular homeostasis, as well as various mechanisms that can lead to both necrosis and apoptosis. The field of "mitochondrial medicine" is emerging in which injury/disease states are targeted therapeutically at the level of the mitochondrion, including specific antioxidants, bioenergetic substrate additions, and membrane uncoupling agents. Consequently, novel mitochondrial transplantation strategies represent a potentially multifactorial therapy leading to increased adenosine triphosphate production, decreased oxidative stress, mitochondrial DNA replacement, improved bioenergetics and tissue sparing. Herein, we describe briefly the history of mitochondrial transplantation and the various techniques used for both in vitro and in vivo delivery, the benefits associated with successful transference into both peripheral and central nervous system tissues, along with caveats and pitfalls that hinder the advancements of this novel therapeutic.

Original language	English
Pages (from-to)	194-197
Number of pages	4
Journal	Neural Regeneration Research
Volume	13
Issue number	2
DOIs	https://doi.org/10.4103/1673-5374.226382
State	Published - Feb 2018

Bibliographical note

Funding Information:
Author contributions: JLG, SPP and AGR wrote the paper. Conflicts of interest: None declared. Financial support: This work was funded by NIH R21NS096670 (AGR), University of Kentucky Spinal Cord and Brain Injury Research Center Chair Endowment (AGR), NIH/NINDS 2P30NS051220. Plagiarism check: Checked twice by iThenticate. Peer review: Externally peer reviewed. Open access statement: This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-Shar-eAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under identical terms.

Funding Information:
Funding: This work was funded by NIH R21NS096670 (AGR), University of Kentucky Spinal Cord and Brain Injury Research Center Chair Endowment (AGR), NIH/NINDS 2P30NS051220.

Publisher Copyright:
© 2018 Wolters Kluwer Medknow Publications. All rights reserved.

Keywords

Bioenergetics
Cellular uptake
Mitochondria
Oxidative phosphorylation
Oxygen consumption
Replacement strategies
Spinal cord injury

ASJC Scopus subject areas

Developmental Neuroscience

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10.4103/1673-5374.226382

Cite this

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title = "Mitochondrial transplantation strategies as potential therapeutics for central nervous system trauma",

abstract = "Mitochondria are essential cellular organelles critical for generating adenosine triphosphate for cellular homeostasis, as well as various mechanisms that can lead to both necrosis and apoptosis. The field of {"}mitochondrial medicine{"} is emerging in which injury/disease states are targeted therapeutically at the level of the mitochondrion, including specific antioxidants, bioenergetic substrate additions, and membrane uncoupling agents. Consequently, novel mitochondrial transplantation strategies represent a potentially multifactorial therapy leading to increased adenosine triphosphate production, decreased oxidative stress, mitochondrial DNA replacement, improved bioenergetics and tissue sparing. Herein, we describe briefly the history of mitochondrial transplantation and the various techniques used for both in vitro and in vivo delivery, the benefits associated with successful transference into both peripheral and central nervous system tissues, along with caveats and pitfalls that hinder the advancements of this novel therapeutic.",

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note = "Funding Information: Author contributions: JLG, SPP and AGR wrote the paper. Conflicts of interest: None declared. Financial support: This work was funded by NIH R21NS096670 (AGR), University of Kentucky Spinal Cord and Brain Injury Research Center Chair Endowment (AGR), NIH/NINDS 2P30NS051220. Plagiarism check: Checked twice by iThenticate. Peer review: Externally peer reviewed. Open access statement: This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-Shar-eAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under identical terms. Funding Information: Funding: This work was funded by NIH R21NS096670 (AGR), University of Kentucky Spinal Cord and Brain Injury Research Center Chair Endowment (AGR), NIH/NINDS 2P30NS051220. Publisher Copyright: {\textcopyright} 2018 Wolters Kluwer Medknow Publications. All rights reserved.",

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AU - Patel, Samir P.

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AB - Mitochondria are essential cellular organelles critical for generating adenosine triphosphate for cellular homeostasis, as well as various mechanisms that can lead to both necrosis and apoptosis. The field of "mitochondrial medicine" is emerging in which injury/disease states are targeted therapeutically at the level of the mitochondrion, including specific antioxidants, bioenergetic substrate additions, and membrane uncoupling agents. Consequently, novel mitochondrial transplantation strategies represent a potentially multifactorial therapy leading to increased adenosine triphosphate production, decreased oxidative stress, mitochondrial DNA replacement, improved bioenergetics and tissue sparing. Herein, we describe briefly the history of mitochondrial transplantation and the various techniques used for both in vitro and in vivo delivery, the benefits associated with successful transference into both peripheral and central nervous system tissues, along with caveats and pitfalls that hinder the advancements of this novel therapeutic.

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Mitochondrial transplantation strategies as potential therapeutics for central nervous system trauma

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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