Mitochondria are essential cellular organelles critical for generating adenosine triphosphate for cellular homeostasis, as well as various mechanisms that can lead to both necrosis and apoptosis. The field of "mitochondrial medicine" is emerging in which injury/disease states are targeted therapeutically at the level of the mitochondrion, including specific antioxidants, bioenergetic substrate additions, and membrane uncoupling agents. Consequently, novel mitochondrial transplantation strategies represent a potentially multifactorial therapy leading to increased adenosine triphosphate production, decreased oxidative stress, mitochondrial DNA replacement, improved bioenergetics and tissue sparing. Herein, we describe briefly the history of mitochondrial transplantation and the various techniques used for both in vitro and in vivo delivery, the benefits associated with successful transference into both peripheral and central nervous system tissues, along with caveats and pitfalls that hinder the advancements of this novel therapeutic.
|Number of pages||4|
|Journal||Neural Regeneration Research|
|State||Published - Feb 2018|
Bibliographical noteFunding Information:
Author contributions: JLG, SPP and AGR wrote the paper. Conflicts of interest: None declared. Financial support: This work was funded by NIH R21NS096670 (AGR), University of Kentucky Spinal Cord and Brain Injury Research Center Chair Endowment (AGR), NIH/NINDS 2P30NS051220. Plagiarism check: Checked twice by iThenticate. Peer review: Externally peer reviewed. Open access statement: This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-Shar-eAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under identical terms.
Funding: This work was funded by NIH R21NS096670 (AGR), University of Kentucky Spinal Cord and Brain Injury Research Center Chair Endowment (AGR), NIH/NINDS 2P30NS051220.
© 2018 Wolters Kluwer Medknow Publications. All rights reserved.
- Cellular uptake
- Oxidative phosphorylation
- Oxygen consumption
- Replacement strategies
- Spinal cord injury
ASJC Scopus subject areas
- Developmental Neuroscience