Mitochondrial transplantation strategies as potential therapeutics for central nervous system trauma

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations

Abstract

Mitochondria are essential cellular organelles critical for generating adenosine triphosphate for cellular homeostasis, as well as various mechanisms that can lead to both necrosis and apoptosis. The field of "mitochondrial medicine" is emerging in which injury/disease states are targeted therapeutically at the level of the mitochondrion, including specific antioxidants, bioenergetic substrate additions, and membrane uncoupling agents. Consequently, novel mitochondrial transplantation strategies represent a potentially multifactorial therapy leading to increased adenosine triphosphate production, decreased oxidative stress, mitochondrial DNA replacement, improved bioenergetics and tissue sparing. Herein, we describe briefly the history of mitochondrial transplantation and the various techniques used for both in vitro and in vivo delivery, the benefits associated with successful transference into both peripheral and central nervous system tissues, along with caveats and pitfalls that hinder the advancements of this novel therapeutic.

Original languageEnglish
Pages (from-to)194-197
Number of pages4
JournalNeural Regeneration Research
Volume13
Issue number2
DOIs
StatePublished - Feb 2018

Bibliographical note

Publisher Copyright:
© 2018 Wolters Kluwer Medknow Publications. All rights reserved.

Keywords

  • Bioenergetics
  • Cellular uptake
  • Mitochondria
  • Oxidative phosphorylation
  • Oxygen consumption
  • Replacement strategies
  • Spinal cord injury

ASJC Scopus subject areas

  • Developmental Neuroscience

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