Modeling low frequency cardiorespiratory interaction using broadband hypoxic stimulation

Sachin Mullick, Eugene Bruce, Andrew Cross, Abhijit Patwardhan

Research output: Contribution to conferencePaperpeer-review

Abstract

We investigated cardiorespiratory dynamic interaction within the low frequency region (<0.15 Hz) using broadband hypoxic stimulation during mean inspired oxygen levels of 16.5% and 12.5%. Spectral broadening of O2 level was obtained by pseudo random binary switching (PRBS) of inspired O2 level between 21% O2 and 4% (12% for mild hypoxia), balance nitrogen. Coherence analysis showed that during moderate hypoxia, responses of R-R interval, BP and ventilation were statistically related. Partial coherences showed fluctuations in R-R interval and Ventilation were correlated in the low frequency region. Parametric modeling resulted in a model with four poles and two zeros as a best fit between FIO2 and R-R interval.

Original languageEnglish
Pages386-389
Number of pages4
StatePublished - 1997
EventProceedings of the 1997 16th Southern Biomedical Engineering Conference - Biloxi, MS, USA
Duration: Apr 4 1997Apr 6 1997

Conference

ConferenceProceedings of the 1997 16th Southern Biomedical Engineering Conference
CityBiloxi, MS, USA
Period4/4/974/6/97

ASJC Scopus subject areas

  • Engineering (all)

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