TY - JOUR
T1 - Modes of defining atherosclerosis in mouse models
T2 - relative merits and evolving standards.
AU - Daugherty, Alan
AU - Lu, Hong
AU - Howatt, Deborah A.
AU - Rateri, Debra L.
N1 - Copyright:
This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine
PY - 2009
Y1 - 2009
N2 - Mouse models have become the most common model for defining mechanisms of atherosclerotic disease. Many genetic manipulations have enabled the development of atherosclerosis in mice due to either endogenous or diet-induced hypercholesterolemia. This availability of lesion-susceptible mice has facilitated many studies using pharmacological and genetic approaches. Unfortunately, this expansive literature on mouse atherosclerosis has generated many contradictions on the role of specific pathways. A contributor to these inconsistencies may be the multiple modes in which atherosclerosis is evaluated. Also, for each specific technique, there are no consistent standards applied to the measurements. This chapter will discuss the imaging, biochemical, and compositional modes of evaluating atherosclerosis with suggestions for standard execution of these techniques.
AB - Mouse models have become the most common model for defining mechanisms of atherosclerotic disease. Many genetic manipulations have enabled the development of atherosclerosis in mice due to either endogenous or diet-induced hypercholesterolemia. This availability of lesion-susceptible mice has facilitated many studies using pharmacological and genetic approaches. Unfortunately, this expansive literature on mouse atherosclerosis has generated many contradictions on the role of specific pathways. A contributor to these inconsistencies may be the multiple modes in which atherosclerosis is evaluated. Also, for each specific technique, there are no consistent standards applied to the measurements. This chapter will discuss the imaging, biochemical, and compositional modes of evaluating atherosclerosis with suggestions for standard execution of these techniques.
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U2 - 10.1007/978-1-60761-247-6_1
DO - 10.1007/978-1-60761-247-6_1
M3 - Review article
C2 - 19763919
AN - SCOPUS:73949111725
SN - 1064-3745
VL - 573
SP - 1
EP - 15
JO - Methods in Molecular Biology
JF - Methods in Molecular Biology
ER -