Modification of post-PKS tailoring steps through combinatorial biosynthesis

Uwe Rix, Carsten Fischer, Lily L. Remsing, Jürgen Rohr

Research output: Contribution to journalReview articlepeer-review

231 Scopus citations

Abstract

This review covers the highlights of combinatorial biosynthesis applied on post-polyketide synthase modifying enzymes, such as oxygenases, ketoreductases, glycosyl- and methyltransferases, acyltransferases, halogenases, cyclases and aminotransferases. Since this is the first review on this topic, it covers literature from 1985 to 2002, and 248 references are given.

Original languageEnglish
Pages (from-to)542-580
Number of pages39
JournalNatural Product Reports
Volume19
Issue number5
DOIs
StatePublished - Oct 2002

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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