Modular approach to pseudo-neoclerodanes as designer κ-opioid ligands

Alexander M. Sherwood, Samuel E. Williamson, Rachel S. Crowley, Logan M. Abbott, Victor W. Day, Thomas E. Prisinzano

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Informed by previous semisynthetic work on salvinorin A, a modular total synthesis has been developed capable of producing novel compounds targeting the κ-opioid receptor. The strategy has permitted the deliberate simplification and introduction of functionality about the target molecule to provide access to molecular features on salvinorin A otherwise unattainable by semisynthesis. Using this approach, a potent pseudo-neoclerodane κ-opioid receptor ligand (2) has been realized.

Original languageEnglish
Pages (from-to)5414-5417
Number of pages4
JournalOrganic Letters
Issue number19
StatePublished - Oct 6 2017

Bibliographical note

Funding Information:
This work was supported by DA018151 and GM1385 (to T.E.P.), GM008545 (to S.E.W. and R.S.C.), AFPE Predoctoral Fellowship in Pharmaceutical Sciences (to R.S.C.), and NSF-MRI Grant CHE-0923449 (V.W.D.). Support for the NMR instrumentation was provided by NIH Shared Instrumentation Grant #S10RR024664 and NSF Major Research Instrumentation Grant #0320648.

Publisher Copyright:
© 2017 American Chemical Society.

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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