Modular approach to pseudo-neoclerodanes as designer κ-opioid ligands

Alexander M. Sherwood, Samuel E. Williamson, Rachel S. Crowley, Logan M. Abbott, Victor W. Day, Thomas E. Prisinzano

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Informed by previous semisynthetic work on salvinorin A, a modular total synthesis has been developed capable of producing novel compounds targeting the κ-opioid receptor. The strategy has permitted the deliberate simplification and introduction of functionality about the target molecule to provide access to molecular features on salvinorin A otherwise unattainable by semisynthesis. Using this approach, a potent pseudo-neoclerodane κ-opioid receptor ligand (2) has been realized.

Original languageEnglish
Pages (from-to)5414-5417
Number of pages4
JournalOrganic Letters
Volume19
Issue number19
DOIs
StatePublished - Oct 6 2017

Bibliographical note

Publisher Copyright:
© 2017 American Chemical Society.

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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