TY - JOUR
T1 - Modular approach to pseudo-neoclerodanes as designer κ-opioid ligands
AU - Sherwood, Alexander M.
AU - Williamson, Samuel E.
AU - Crowley, Rachel S.
AU - Abbott, Logan M.
AU - Day, Victor W.
AU - Prisinzano, Thomas E.
N1 - Publisher Copyright:
© 2017 American Chemical Society.
PY - 2017/10/6
Y1 - 2017/10/6
N2 - Informed by previous semisynthetic work on salvinorin A, a modular total synthesis has been developed capable of producing novel compounds targeting the κ-opioid receptor. The strategy has permitted the deliberate simplification and introduction of functionality about the target molecule to provide access to molecular features on salvinorin A otherwise unattainable by semisynthesis. Using this approach, a potent pseudo-neoclerodane κ-opioid receptor ligand (2) has been realized.
AB - Informed by previous semisynthetic work on salvinorin A, a modular total synthesis has been developed capable of producing novel compounds targeting the κ-opioid receptor. The strategy has permitted the deliberate simplification and introduction of functionality about the target molecule to provide access to molecular features on salvinorin A otherwise unattainable by semisynthesis. Using this approach, a potent pseudo-neoclerodane κ-opioid receptor ligand (2) has been realized.
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U2 - 10.1021/acs.orglett.7b02684
DO - 10.1021/acs.orglett.7b02684
M3 - Article
C2 - 28910112
AN - SCOPUS:85032618050
SN - 1523-7060
VL - 19
SP - 5414
EP - 5417
JO - Organic Letters
JF - Organic Letters
IS - 19
ER -