TY - JOUR
T1 - Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans
T2 - report of an expert meeting
AU - Sun, Jun
AU - Ince, M. Nedim
AU - Abraham, Clara
AU - Barrett, Terrence
AU - Brenner, Lisa A.
AU - Cong, Yingzi
AU - Dashti, Reza
AU - Dudeja, Pradeep K.
AU - Elliott, David
AU - Griffith, Thomas S.
AU - Heeger, Peter S.
AU - Hoisington, Andrew
AU - Irani, Kaikobad
AU - Kim, Tae Kon
AU - Kapur, Neeraj
AU - Leventhal, Joseph
AU - Mohamadzadeh, Mansour
AU - Mutlu, Ece
AU - Newberry, Rodney
AU - Peled, Jonathan U.
AU - Rubinstein, Israel
AU - Sengsayadeth, Salyka
AU - Tan, Chen Sabrina
AU - Tan, Xiao Di
AU - Tkaczyk, Eric
AU - Wertheim, Jason
AU - Zhang, Zheng Jenny
N1 - Publisher Copyright:
© This work was authored as part of the Contributor’s official duties as an Employee of the United States Government and is therefore a work of the United States Government. In accordance with 17 U.S.C. 105, no copyright protection is available for such works under U.S. Law.
PY - 2023
Y1 - 2023
N2 - The present report summarizes the United States Department of Veterans Affairs (VA) field-based meeting titled “Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans.” Our Veteran patient population experiences a high incidence of service-related chronic physical and mental health problems, such as infection, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), various forms of hematological and non-hematological malignancies, neurologic conditions, end-stage organ failure, requiring transplantation, and posttraumatic stress disorder (PTSD). We report the views of a group of scientists who focus on the current state of scientific knowledge elucidating the mechanisms underlying the aforementioned disorders, novel therapeutic targets, and development of new approaches for clinical intervention. In conclusion, we dovetailed on four research areas of interest: 1) microbiome interaction with immune cells after hematopoietic cell and/or solid organ transplantation, graft-versus-host disease (GVHD) and graft rejection, 2) intestinal inflammation and its modification in IBD and cancer, 3) microbiome-neuron-immunity interplay in mental and physical health, and 4) microbiome-micronutrient-immune interactions during homeostasis and infectious diseases. At this VA field-based meeting, we proposed to explore a multi-disciplinary, multi-institutional, collaborative strategy to initiate a roadmap, specifically focusing on host microbiome-immune interactions among those with service-related chronic diseases to potentially identify novel and translatable therapeutic targets.
AB - The present report summarizes the United States Department of Veterans Affairs (VA) field-based meeting titled “Modulating microbiome-immune axis in the deployment-related chronic diseases of Veterans.” Our Veteran patient population experiences a high incidence of service-related chronic physical and mental health problems, such as infection, irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), various forms of hematological and non-hematological malignancies, neurologic conditions, end-stage organ failure, requiring transplantation, and posttraumatic stress disorder (PTSD). We report the views of a group of scientists who focus on the current state of scientific knowledge elucidating the mechanisms underlying the aforementioned disorders, novel therapeutic targets, and development of new approaches for clinical intervention. In conclusion, we dovetailed on four research areas of interest: 1) microbiome interaction with immune cells after hematopoietic cell and/or solid organ transplantation, graft-versus-host disease (GVHD) and graft rejection, 2) intestinal inflammation and its modification in IBD and cancer, 3) microbiome-neuron-immunity interplay in mental and physical health, and 4) microbiome-micronutrient-immune interactions during homeostasis and infectious diseases. At this VA field-based meeting, we proposed to explore a multi-disciplinary, multi-institutional, collaborative strategy to initiate a roadmap, specifically focusing on host microbiome-immune interactions among those with service-related chronic diseases to potentially identify novel and translatable therapeutic targets.
KW - IBD
KW - Immunity
KW - graft rejection
KW - graft-versus-host disease
KW - gut microbiome
KW - gut-brain-axis
KW - infection
KW - micronutrition
KW - mitochondria
KW - oral microbiome
KW - posttraumatic stress disorder
KW - virome
KW - vitamin
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UR - http://www.scopus.com/inward/citedby.url?scp=85174748947&partnerID=8YFLogxK
U2 - 10.1080/19490976.2023.2267180
DO - 10.1080/19490976.2023.2267180
M3 - Article
C2 - 37842912
AN - SCOPUS:85174748947
SN - 1949-0976
VL - 15
JO - Gut Microbes
JF - Gut Microbes
IS - 2
M1 - 2267180
ER -
