Modulatory effect of Piperine on mitochondrial antioxidant system in Benzo(a)pyrene-induced experimental lung carcinogenesis

K. Selvendiran, P. Senthilnathan, V. Magesh, D. Sakthisekaran

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Chemoprevention has emerged as a very effective preventive measure against carcinogenesis. Many bioactive compounds present in edible as well in herbal plants have revealed their cancer chemopreventive potential. In the present study, our goal was to investigate the impact of piperine, a principle ingredient of pepper, on alterations of mitochondrial antioxidant system and lipid peroxidation in Benzo(a)pyrene (B(a)P) induced experimental lung carcinogenesis. Oral supplementation of piperine (50 mg/kg body weight) effectively suppressed lung carcinogenesis in B(a)p induced mice as revealed by the decrease in the extent of mitochondrial lipid peroxidation and concomitant increase in the activities of enzymatic antioxidants (superoxide dismutase, catalase and glutathione peroxidase) and non enzymatic antioxidant (reduced glutathione, vitamin E and vitamin C) levels when compared to lung carcinogenesis bearing animals. Our data suggests that piperine may extent its chemopreventive effect by modulating lipid peroxidation and augmenting antioxidant defense system.

Original languageEnglish
Pages (from-to)85-89
Number of pages5
Issue number1
StatePublished - Jan 2004

Bibliographical note

Funding Information:
One of the authors K. Selvendiran, gratefully acknowledge the CSIR for the financial assistance given in the form of SRF and also we acknowledge with gratitude Mis. Lesile Karlin, Research associate, National Cancer Institute, MRI, Missouri, USA for her kind gift of Benzo (a) pyrene


  • Benzo(a)Pyrene
  • Lung carcinogenesis
  • Mitochondrial antioxidants
  • Piperine

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine


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