Molecular crowding effects on protein stability.

Florin Despa, Dennis P. Orgill, Raphael C. Lee

Research output: Contribution to journalReview articlepeer-review

53 Scopus citations


The volume fraction occupied by the dry matter of the cell can be as large as 40%, of which more than half (approximately 60%) are proteins. Thus, cellular proteins and protein assemblies occupy a large volume that can have a profound effect on their own native-state stabilities and on their unfolding/refolding rates. In addition, macromolecular crowding can change the properties of a significant fraction of the water in the cell. We review features of the molecular crowding effect which are relevant for describing the microscopic mechanism of thermal injuries.

Original languageEnglish
Pages (from-to)54-66
Number of pages13
JournalAnnals of the New York Academy of Sciences
StatePublished - Mar 1 2006

ASJC Scopus subject areas

  • General Neuroscience
  • General Biochemistry, Genetics and Molecular Biology
  • History and Philosophy of Science


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