Molecular design of novel triblock copolymers and their efficiency as a gene carrier

Shigeto Fukushima, Kanjiro Miyata, Nobuhiro Nishiyama, Naoki Kanayama, Younsoo Bae, Takuya Nakagawa, Keiji Itaka, Yuichi Yamasaki, Kazunori Kataoka

Research output: Contribution to conferencePaperpeer-review


A-B-C type triblock copolymers with the different structure(the type of B segment, the chain length of B, C segment, the order of segments) were synthesized and their efficiency as a gene carrier was evaluated by preparing the polyion complex micelles with plasmid-DNA. The triblock copolymers having B segment with a buffering capacity show the high transfection efficiency. But the A-C-B type triblock copolymer does not show the high efficiency.

Original languageEnglish
Number of pages2
StatePublished - 2005
Event54th SPSJ Symposium on Macromolecules - Yamagata, Japan
Duration: Sep 20 2005Sep 22 2005


Conference54th SPSJ Symposium on Macromolecules


  • Ester-amide Exchange
  • Gene Carrier
  • Polycation
  • Polyethylene Glycol
  • Triblock Copolymer

ASJC Scopus subject areas

  • General Engineering


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