Molecular design of novel triblock copolymers and their efficiency as a gene carrier

Shigeto Fukushima; Kanjiro Miyata; Nobuhiro Nishiyama; Naoki Kanayama; Younsoo Bae; Takuya Nakagawa; Keiji Itaka; Yuichi Yamasaki; Kazunori Kataoka

Molecular design of novel triblock copolymers and their efficiency as a gene carrier

Shigeto Fukushima
, Kanjiro Miyata
, Nobuhiro Nishiyama
, Naoki Kanayama
, Younsoo Bae
, Takuya Nakagawa
, Keiji Itaka
, Yuichi Yamasaki
, Kazunori Kataoka

Research output: Contribution to conference › Paper › peer-review

Abstract

A-B-C type triblock copolymers with the different structure(the type of B segment, the chain length of B, C segment, the order of segments) were synthesized and their efficiency as a gene carrier was evaluated by preparing the polyion complex micelles with plasmid-DNA. The triblock copolymers having B segment with a buffering capacity show the high transfection efficiency. But the A-C-B type triblock copolymer does not show the high efficiency.

Original language	English
Pages	5185-5186
Number of pages	2
State	Published - 2005
Event	54th SPSJ Symposium on Macromolecules - Yamagata, Japan Duration: Sep 20 2005 → Sep 22 2005

Conference

Conference	54th SPSJ Symposium on Macromolecules
Country/Territory	Japan
City	Yamagata
Period	9/20/05 → 9/22/05

Keywords

Ester-amide Exchange
Gene Carrier
Polycation
Polyethylene Glycol
Triblock Copolymer

ASJC Scopus subject areas

General Engineering

Cite this

@conference{2ccb1dbc2d2c416e8f4474665ded1191,

title = "Molecular design of novel triblock copolymers and their efficiency as a gene carrier",

abstract = "A-B-C type triblock copolymers with the different structure(the type of B segment, the chain length of B, C segment, the order of segments) were synthesized and their efficiency as a gene carrier was evaluated by preparing the polyion complex micelles with plasmid-DNA. The triblock copolymers having B segment with a buffering capacity show the high transfection efficiency. But the A-C-B type triblock copolymer does not show the high efficiency.",

keywords = "Ester-amide Exchange, Gene Carrier, Polycation, Polyethylene Glycol, Triblock Copolymer",

author = "Shigeto Fukushima and Kanjiro Miyata and Nobuhiro Nishiyama and Naoki Kanayama and Younsoo Bae and Takuya Nakagawa and Keiji Itaka and Yuichi Yamasaki and Kazunori Kataoka",

year = "2005",

language = "English",

pages = "5185--5186",

note = "54th SPSJ Symposium on Macromolecules ; Conference date: 20-09-2005 Through 22-09-2005",

}

TY - CONF

T1 - Molecular design of novel triblock copolymers and their efficiency as a gene carrier

AU - Fukushima, Shigeto

AU - Miyata, Kanjiro

AU - Nishiyama, Nobuhiro

AU - Kanayama, Naoki

AU - Bae, Younsoo

AU - Nakagawa, Takuya

AU - Itaka, Keiji

AU - Yamasaki, Yuichi

AU - Kataoka, Kazunori

PY - 2005

Y1 - 2005

N2 - A-B-C type triblock copolymers with the different structure(the type of B segment, the chain length of B, C segment, the order of segments) were synthesized and their efficiency as a gene carrier was evaluated by preparing the polyion complex micelles with plasmid-DNA. The triblock copolymers having B segment with a buffering capacity show the high transfection efficiency. But the A-C-B type triblock copolymer does not show the high efficiency.

AB - A-B-C type triblock copolymers with the different structure(the type of B segment, the chain length of B, C segment, the order of segments) were synthesized and their efficiency as a gene carrier was evaluated by preparing the polyion complex micelles with plasmid-DNA. The triblock copolymers having B segment with a buffering capacity show the high transfection efficiency. But the A-C-B type triblock copolymer does not show the high efficiency.

KW - Ester-amide Exchange

KW - Gene Carrier

KW - Polycation

KW - Polyethylene Glycol

KW - Triblock Copolymer

UR - https://www.scopus.com/pages/publications/33645571296

UR - https://www.scopus.com/pages/publications/33645571296#tab=citedBy

M3 - Paper

AN - SCOPUS:33645571296

SP - 5185

EP - 5186

T2 - 54th SPSJ Symposium on Macromolecules

Y2 - 20 September 2005 through 22 September 2005

ER -

Molecular design of novel triblock copolymers and their efficiency as a gene carrier

Abstract

Conference

Keywords

ASJC Scopus subject areas

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