TY - JOUR
T1 - Molecular mechanisms of metabolic associated fatty liver disease (MAFLD)
T2 - functional analysis of lipid metabolism pathways
AU - Badmus, Olufunto O.
AU - Hillhouse, Sarah A.
AU - Anderson, Christopher D.
AU - Hinds, Terry D.
AU - Stec, David E.
N1 - Publisher Copyright:
© 2022 The Author(s).
PY - 2022/9
Y1 - 2022/9
N2 - The metabolic-associated fatty liver disease (MAFLD) is a condition of fat accumulation in the liver in combination with metabolic dysfunction in the form of overweight or obesity and insulin resistance. It is also associated with an increased cardiovascular disease risk, including hypertension and atherosclerosis. Hepatic lipid metabolism is regulated by a combination of the uptake and export of fatty acids, de novo lipogenesis, and fat utilization by β-oxidation. When the balance between these pathways is altered, hepatic lipid accumulation commences, and long-term activation of inflammatory and fibrotic pathways can progress to worsen the liver disease. This review discusses the details of the molecular mechanisms regulating hepatic lipids and the emerging therapies targeting these pathways as potential future treatments for MAFLD.
AB - The metabolic-associated fatty liver disease (MAFLD) is a condition of fat accumulation in the liver in combination with metabolic dysfunction in the form of overweight or obesity and insulin resistance. It is also associated with an increased cardiovascular disease risk, including hypertension and atherosclerosis. Hepatic lipid metabolism is regulated by a combination of the uptake and export of fatty acids, de novo lipogenesis, and fat utilization by β-oxidation. When the balance between these pathways is altered, hepatic lipid accumulation commences, and long-term activation of inflammatory and fibrotic pathways can progress to worsen the liver disease. This review discusses the details of the molecular mechanisms regulating hepatic lipids and the emerging therapies targeting these pathways as potential future treatments for MAFLD.
UR - http://www.scopus.com/inward/record.url?scp=85138413961&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85138413961&partnerID=8YFLogxK
U2 - 10.1042/CS20220572
DO - 10.1042/CS20220572
M3 - Review article
C2 - 36148775
AN - SCOPUS:85138413961
SN - 0143-5221
VL - 136
SP - 1347
EP - 1366
JO - Clinical Science
JF - Clinical Science
IS - 18
ER -