Molecular mechanisms of metal toxicity and carcinogenesis

S. Wang, X. Shi

Research output: Contribution to journalArticlepeer-review

205 Scopus citations


Many metals and metal-containing compounds have been identified to be potent mutagens and carcinogens. Recently, a new sub-discipline of molecular toxicology and carcinogenesis has been developed. The combination of newly developed molecular techniques and free radical approach makes it possible to insightfully examine metal-induced carcinogenesis in precise molecular terms so that intricate biological interrelationships can be elucidated. In consideration of the increased amount of new findings deciphered by utilizing these new methods, the 1st Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis was held. In this conference, more than 50 scientists from nine countries presented their novel discoveries concerning metal-induced carcinogenesis, delineated molecular mechanism of metal carcinogenesis, and proposed novel therapeutic intervention and prevention strategies. This article reviews some of the state-of-the-art information presented at the meeting regarding the molecular mechanisms of metal cytotoxicity and carcinogenesis.

Original languageEnglish
Pages (from-to)3-9
Number of pages7
JournalMolecular and Cellular Biochemistry
Issue number1-2
StatePublished - 2001

Bibliographical note

Funding Information:
The authors thank Drs Vince Castranova, Murali Rao, and Val Vallyathan for a critical reading of the manuscript. Research funded under Interagency Agreement number 98-18-00m2 between the Occupational Safety and Health Administration (OSHA) and the National Institute for Occupational Safety and Health (NIOSH). The views exp ressed in the p ap er are those of the authors and do not necessarily reflect the official position of OSHA.


  • Cell growth regulation
  • Cytotoxicity and carcinogenesis
  • ROS
  • Signal transduction
  • Transcription factor

ASJC Scopus subject areas

  • Molecular Biology
  • Clinical Biochemistry
  • Cell Biology


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