TY - JOUR
T1 - Monoaminergic influences on temporal patterning of sexual behavior in male rats
AU - Yells, David P.
AU - Prendergast, Mark A.
AU - Hendricks, Shelton E.
AU - Miller, Marnie E.
PY - 1995/11
Y1 - 1995/11
N2 - We evaluated the effects of the serotonin (5-HT) presynaptic uptake blocker fluoxetine (FLX) and the dopamine (DA)/noradrenaline (NE) releaser amantadine (AMA), separately and in combination, on the temporal patterning of male rat sexual behavior. FLX alone increased intermount-bout intervals, time-outs, grooming time, ejaculation latency, number of mounts per mount bout, and number of mount bouts per ejaculation. AMA alone had the opposite effect on these measures. Additionally, AMA, when given in combination with FLX, completely reversed the FLX-induced deficits in copulatory behavior. We interpret our results as suggesting an interaction between 5-HT and catecholamines in the temporal patterning of male rat copulatorybehavior. Monamines.
AB - We evaluated the effects of the serotonin (5-HT) presynaptic uptake blocker fluoxetine (FLX) and the dopamine (DA)/noradrenaline (NE) releaser amantadine (AMA), separately and in combination, on the temporal patterning of male rat sexual behavior. FLX alone increased intermount-bout intervals, time-outs, grooming time, ejaculation latency, number of mounts per mount bout, and number of mount bouts per ejaculation. AMA alone had the opposite effect on these measures. Additionally, AMA, when given in combination with FLX, completely reversed the FLX-induced deficits in copulatory behavior. We interpret our results as suggesting an interaction between 5-HT and catecholamines in the temporal patterning of male rat copulatorybehavior. Monamines.
KW - Copulatory behavior
KW - Ejaculation
KW - Fluoxetine
KW - Grooming
KW - Noradrenaline
KW - Sex
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U2 - 10.1016/0031-9384(95)00130-B
DO - 10.1016/0031-9384(95)00130-B
M3 - Article
C2 - 8577879
AN - SCOPUS:0028972618
SN - 0031-9384
VL - 58
SP - 847
EP - 852
JO - Physiology and Behavior
JF - Physiology and Behavior
IS - 5
ER -