Monoaminergic influences on temporal patterning of sexual behavior in male rats

David P. Yells, Mark A. Prendergast, Shelton E. Hendricks, Marnie E. Miller

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


We evaluated the effects of the serotonin (5-HT) presynaptic uptake blocker fluoxetine (FLX) and the dopamine (DA)/noradrenaline (NE) releaser amantadine (AMA), separately and in combination, on the temporal patterning of male rat sexual behavior. FLX alone increased intermount-bout intervals, time-outs, grooming time, ejaculation latency, number of mounts per mount bout, and number of mount bouts per ejaculation. AMA alone had the opposite effect on these measures. Additionally, AMA, when given in combination with FLX, completely reversed the FLX-induced deficits in copulatory behavior. We interpret our results as suggesting an interaction between 5-HT and catecholamines in the temporal patterning of male rat copulatorybehavior. Monamines.

Original languageEnglish
Pages (from-to)847-852
Number of pages6
JournalPhysiology and Behavior
Issue number5
StatePublished - Nov 1995


  • Copulatory behavior
  • Ejaculation
  • Fluoxetine
  • Grooming
  • Noradrenaline
  • Sex

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience


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