TY - JOUR
T1 - Moromycins A and B, isolation and structure elucidation of C-glycosylangucycline-type antibiotics from Streptomyces sp. KY002
AU - Abdelfattah, Mohamed S.
AU - Kharel, Madan Kumar
AU - Hitron, John Andrew
AU - Baig, Irfan
AU - Rohr, Jürgen
PY - 2008/9
Y1 - 2008/9
N2 - Two new anticancer antibiotics of the angucycline class, moromycins A and B (1, 2), along with the known microbial metabolites saquayamycin B (3) and fridamycin D (4) were isolated from the ethyl acetate extract of a culture broth of the terrestrial Streptomyces sp. KY002. The structures consist of a tetrangomycin core and various C- and O-glycosidically linked deoxysugars. The chemical structures of the new secondary metabolites were elucidated by 1D and 2D NMR and by mass spectrometry. Moromycin B (2) showed significant cytotoxicity against H-460 human lung cancer and MCF-7 human breast cancer cells.
AB - Two new anticancer antibiotics of the angucycline class, moromycins A and B (1, 2), along with the known microbial metabolites saquayamycin B (3) and fridamycin D (4) were isolated from the ethyl acetate extract of a culture broth of the terrestrial Streptomyces sp. KY002. The structures consist of a tetrangomycin core and various C- and O-glycosidically linked deoxysugars. The chemical structures of the new secondary metabolites were elucidated by 1D and 2D NMR and by mass spectrometry. Moromycin B (2) showed significant cytotoxicity against H-460 human lung cancer and MCF-7 human breast cancer cells.
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U2 - 10.1021/np800281f
DO - 10.1021/np800281f
M3 - Article
C2 - 18666798
AN - SCOPUS:54149108592
SN - 0163-3864
VL - 71
SP - 1569
EP - 1573
JO - Journal of Natural Products
JF - Journal of Natural Products
IS - 9
ER -
