Moromycins A and B, isolation and structure elucidation of C-glycosylangucycline-type antibiotics from Streptomyces sp. KY002

Mohamed S. Abdelfattah; Madan Kumar Kharel; John Andrew Hitron; Irfan Baig; Jürgen Rohr

doi:10.1021/np800281f

Moromycins A and B, isolation and structure elucidation of C-glycosylangucycline-type antibiotics from Streptomyces sp. KY002

Mohamed S. Abdelfattah
, Madan Kumar Kharel
, John Andrew Hitron
, Irfan Baig
, Jürgen Rohr

Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Two new anticancer antibiotics of the angucycline class, moromycins A and B (1, 2), along with the known microbial metabolites saquayamycin B (3) and fridamycin D (4) were isolated from the ethyl acetate extract of a culture broth of the terrestrial Streptomyces sp. KY002. The structures consist of a tetrangomycin core and various C- and O-glycosidically linked deoxysugars. The chemical structures of the new secondary metabolites were elucidated by 1D and 2D NMR and by mass spectrometry. Moromycin B (2) showed significant cytotoxicity against H-460 human lung cancer and MCF-7 human breast cancer cells.

Original language	English
Pages (from-to)	1569-1573
Number of pages	5
Journal	Journal of Natural Products
Volume	71
Issue number	9
DOIs	https://doi.org/10.1021/np800281f
State	Published - Sep 2008

Funding

Funders	Funder number
National Childhood Cancer Registry – National Cancer Institute	R01CA102102

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

Access to Document

10.1021/np800281f

Cite this

@article{d2d1585024d6435e991b429854375f3d,

title = "Moromycins A and B, isolation and structure elucidation of C-glycosylangucycline-type antibiotics from Streptomyces sp. KY002",

abstract = "Two new anticancer antibiotics of the angucycline class, moromycins A and B (1, 2), along with the known microbial metabolites saquayamycin B (3) and fridamycin D (4) were isolated from the ethyl acetate extract of a culture broth of the terrestrial Streptomyces sp. KY002. The structures consist of a tetrangomycin core and various C- and O-glycosidically linked deoxysugars. The chemical structures of the new secondary metabolites were elucidated by 1D and 2D NMR and by mass spectrometry. Moromycin B (2) showed significant cytotoxicity against H-460 human lung cancer and MCF-7 human breast cancer cells.",

author = "Abdelfattah, \{Mohamed S.\} and Kharel, \{Madan Kumar\} and Hitron, \{John Andrew\} and Irfan Baig and J{\"u}rgen Rohr",

year = "2008",

month = sep,

doi = "10.1021/np800281f",

language = "English",

volume = "71",

pages = "1569--1573",

number = "9",

}

TY - JOUR

T1 - Moromycins A and B, isolation and structure elucidation of C-glycosylangucycline-type antibiotics from Streptomyces sp. KY002

AU - Abdelfattah, Mohamed S.

AU - Kharel, Madan Kumar

AU - Hitron, John Andrew

AU - Baig, Irfan

AU - Rohr, Jürgen

PY - 2008/9

Y1 - 2008/9

N2 - Two new anticancer antibiotics of the angucycline class, moromycins A and B (1, 2), along with the known microbial metabolites saquayamycin B (3) and fridamycin D (4) were isolated from the ethyl acetate extract of a culture broth of the terrestrial Streptomyces sp. KY002. The structures consist of a tetrangomycin core and various C- and O-glycosidically linked deoxysugars. The chemical structures of the new secondary metabolites were elucidated by 1D and 2D NMR and by mass spectrometry. Moromycin B (2) showed significant cytotoxicity against H-460 human lung cancer and MCF-7 human breast cancer cells.

AB - Two new anticancer antibiotics of the angucycline class, moromycins A and B (1, 2), along with the known microbial metabolites saquayamycin B (3) and fridamycin D (4) were isolated from the ethyl acetate extract of a culture broth of the terrestrial Streptomyces sp. KY002. The structures consist of a tetrangomycin core and various C- and O-glycosidically linked deoxysugars. The chemical structures of the new secondary metabolites were elucidated by 1D and 2D NMR and by mass spectrometry. Moromycin B (2) showed significant cytotoxicity against H-460 human lung cancer and MCF-7 human breast cancer cells.

UR - https://www.scopus.com/pages/publications/54149108592

UR - https://www.scopus.com/pages/publications/54149108592#tab=citedBy

U2 - 10.1021/np800281f

DO - 10.1021/np800281f

M3 - Article

C2 - 18666798

AN - SCOPUS:54149108592

SN - 0163-3864

VL - 71

SP - 1569

EP - 1573

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 9

ER -

Moromycins A and B, isolation and structure elucidation of C-glycosylangucycline-type antibiotics from Streptomyces sp. KY002

Abstract

Funding

UN SDGs

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this