Morphine-conditioned analgesia using a taste cue: dissociation of taste aversion and analgesia

M. T. Bardo, J. M. Valone

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


The present study examined the ability of a taste cue to serve as a conditioned stimulus (CS) for conditioning the analgesic effect of morphine. Rats were given three pairings of a taste CS with a morphine unconditioned stimulus (US). As expected, there was a decrease in CS intake across repeated pairings, indicating that a conditioned taste aversion was obtained. More important, presentation of the CS alone also increased paw-lick latencies on a hot plate test (either 50°C or 54°C hot plate), suggesting that an analgesic conditioned response (CR) was obtained. The dose of morphine required to produce conditioned analgesia was higher than the dose of morphine required to produce conditioned taste aversion. Using 15 mg/kg morphine, however, both conditioned taste aversion and conditioned analgesia were present when the morphine US was given immediately following CS intake, but not when given 6 h following CS intake. In contrast to morphine, pairing a taste CS with lithium produced a conditioned taste aversion without any conditioned analgesic response. These results indicate that acquisition of an analgesic CR is not the result of stress induced by an aversion to the taste CS.

Original languageEnglish
Pages (from-to)269-274
Number of pages6
Issue number2
StatePublished - Mar 1994


  • Analgesia
  • Conditioned analgesia
  • Conditioned taste aversion
  • Lithium
  • Morphine

ASJC Scopus subject areas

  • Pharmacology


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